Duchenne muscular dystrophy is a severe, progressive, muscle-wasting disease that leads
to difficulties with movement and, eventually, to the need for assisted ventilation and …

Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes,
cancer, renal, and cardiac failure and in aging-sarcopenia. In these catabolic conditions the …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–
proteasome system (UPS) is recognised as a major intracellular protein degradation system …

Despite the extensive genetic and phenotypic variations present in the different tumors, they
frequently share common metabolic alterations, such as autophagy. Autophagy is a self …

Nothing is known about the potential implication of gut microbiota in skeletal muscle
disorders. Here, we provide evidence that fecal microbiota composition along with …

Autophagy, a cellular self-eating mechanism, is important for maintaining cell survival and
tissue homeostasis in various stressed conditions. Although the molecular mechanism of …

Two decades ago, the recognition of protein misfolding and aggregate accumulation as
defining features of neurodegenerative disease set the stage for a thorough examination of …

Recent studies have correlated physical activity with a better prognosis in cachectic patients,
although the underlying mechanisms are not yet understood. In order to identify the …

Functional denervation is a hallmark of aging sarcopenia as well as of muscular dystrophy. It
is thought to be a major factor reducing skeletal muscle mass, particularly in the case of …