Muscle atrophy derived from excessive proteolysis is a hallmark of numerous disease
conditions. Accordingly, the negative consequences of skeletal muscle protein breakdown …

The movement of proteins between cellular compartments requires the orchestrated actions
of many factors including Rab family GTPases, Soluble NSF Attachment protein REceptors …

Our understanding of the molecular mechanisms underlying adaptations to resistance
exercise remains elusive despite the significant biological and clinical relevance. We …

Background and Purpose Duchenne muscular dystrophy (DMD), caused by dystrophin
deficiency, results in chronic inflammation and irreversible skeletal muscle degeneration …

Klotho is a powerful longevity protein that has been linked to the prevention of muscle
atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been …

Optimal autophagic activity is crucial to maintain muscle integrity, with either reduced or
excessive levels leading to specific myopathies. LGMD2H is a muscle dystrophy caused by …

Skeletal muscle is a pivotal organ in humans that maintains locomotion and homeostasis.
Muscle atrophy caused by sarcopenia and cachexia, which results in reduced muscle mass …

Centronuclear myopathies (CNMs) are a genetically heterogeneous group of inherited
neuromuscular disorders characterized by clinical features of a congenital myopathy and …

Elevation of intraocular pressure (IOP) due to trabecular meshwork (TM) damage is
associated with primary open-angle glaucoma (POAG). Myocilin mutations resulting in …

Sarcopenia is the aging-associated progressive loss of skeletal muscle; however, the
pathogenic mechanism of sarcopenia is not clear. The orexigenic hormone ghrelin …