Oxidative stress in amyotrophic lateral sclerosis: pathophysiology and opportunities for pharmacological intervention

T Cunha-Oliveira, L Montezinho… - Oxidative medicine …, 2020 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot
disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to …

Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach

S Singh, TG Singh - Current Neuropharmacology, 2020 - ingentaconnect.com
A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

Nearly 30 years of animal models to study amyotrophic lateral sclerosis: a historical overview and future perspectives

T Bonifacino, RA Zerbo, M Balbi, C Torazza… - International journal of …, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

[HTML][HTML] Masitinib: The promising actor in the next season of the Amyotrophic Lateral Sclerosis treatment series

AHME Ketabforoush, R Chegini, S Barati… - Biomedicine & …, 2023 - Elsevier
Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with high
mortality and morbidity rate affecting both upper and lower motor neurons (MN). Muscle …

Parenteral microemulsion for drug delivery: Advances and update

VP Chavda, N Gogoi, DA Vaghela, PC Balar… - Journal of Drug Delivery …, 2023 - Elsevier
Patients with chronic conditions often need to adhere to long-term medication regimens,
requiring them to take medication daily for an extended period. Nevertheless, the …

[HTML][HTML] Advances in nanotechnology-based strategies for the treatments of amyotrophic lateral sclerosis

GY Wang, SL Rayner, R Chung, BY Shi, XJ Liang - Materials Today Bio, 2020 - Elsevier
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a
progressive neurodegenerative disease that affects both upper and lower motor neurons …

The global economic impact of neurodegenerative diseases: Opportunities and challenges

W Zahra, SN Rai, H Birla, SS Singh, H Dilnashin… - Bioeconomy for …, 2020 - Springer
The main challenge in today's world to the healthcare system is the elevated occurrence of
the neurodegenerative disorders. Progress in the field of bioinformatics and biomedical …

The role of the microbiota–gut–brain axis and antibiotics in ALS and neurodegenerative diseases

M Obrenovich, H Jaworski, T Tadimalla, A Mistry… - Microorganisms, 2020 - mdpi.com
The human gut hosts a wide and diverse ecosystem of microorganisms termed the
microbiota, which line the walls of the digestive tract and colon where they co-metabolize …

A state of the art of antioxidant properties of curcuminoids in neurodegenerative diseases

S Silvestro, C Sindona, P Bramanti… - International Journal of …, 2021 - mdpi.com
Neurodegenerative diseases represent a set of pathologies characterized by an irreversible
and progressive, and a loss of neuronal cells in specific areas of the brain. Oxidative …

Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes

C Torazza, F Provenzano, E Gallia, M Cerminara… - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
progressive degeneration of motor neurons (MNs). Astrocytes display a toxic phenotype in …