Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans
Parental care influences development across mammals. In humans such influences include
effects on phenotypes, such as stress reactivity, which determine individual differences in …
effects on phenotypes, such as stress reactivity, which determine individual differences in …
The social environment and the epigenome
The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …
The urokinase plasminogen activator system: a target for anti-cancer therapy
S Ulisse, E Baldini, S Sorrenti… - Current cancer drug …, 2009 - ingentaconnect.com
The urokinase plasminogen activator (uPA) system (uPAS) consists of the uPA, its cognate
receptor (uPAR) and two specific inhibitors, the plasminogen activator inhibitor 1 (PAI-1) and …
receptor (uPAR) and two specific inhibitors, the plasminogen activator inhibitor 1 (PAI-1) and …
GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes
MO Poulter, L Du, ICG Weaver, M Palkovits, G Faludi… - Biological …, 2008 - Elsevier
BACKGROUND: Epigenetic mechanisms may be involved in the reprogramming of gene
expression in response to stressful stimuli. This investigation determined whether epigenetic …
expression in response to stressful stimuli. This investigation determined whether epigenetic …
Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with …
J Ying, H Li, TJ Seng, C Langford, G Srivastava… - Oncogene, 2006 - nature.com
Protocadherins constitute the largest subgroup in the cadherin superfamily of cell adhesion
molecules. Their major functions are poorly understood, although some are implicated in …
molecules. Their major functions are poorly understood, although some are implicated in …
Causes and consequences of DNA hypomethylation in human cancer
MJ Hoffmann, WA Schulz - Biochemistry and cell biology, 2005 - cdnsciencepub.com
While specific genes are hypermethylated in the genome of cancer cells, overall
methylcytosine content is often decreased as a consequence of hypomethylation affecting …
methylcytosine content is often decreased as a consequence of hypomethylation affecting …
Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes
S Milutinovic, AC D'Alessio, N Detich, M Szyf - Carcinogenesis, 2007 - academic.oup.com
Valproate (VPA) 1 has been used for decades in the treatment of epilepsy, and is also
effective as a mood stabilizer and in migraine therapy. It has been shown that VPA is also a …
effective as a mood stabilizer and in migraine therapy. It has been shown that VPA is also a …
Global levels of specific histone modifications and an epigenetic gene signature predict prostate cancer progression and development
Background: Epigenetic alterations are common in prostate cancer, yet how these
modifications contribute to carcinogenesis is poorly understood. We investigated whether …
modifications contribute to carcinogenesis is poorly understood. We investigated whether …
Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells
K Kato, NK Long, H Makita, M Toida… - British journal of …, 2008 - nature.com
RECK is a novel tumour suppressor gene that negatively regulates matrix
metalloproteinases (MMPs) and inhibits tumour invasion, angiogenesis and metastasis. In …
metalloproteinases (MMPs) and inhibits tumour invasion, angiogenesis and metastasis. In …
How lifetimes shape epigenotype within and across generations
NC Whitelaw, E Whitelaw - Human molecular genetics, 2006 - academic.oup.com
Despite our detailed characterization of the human genome at the level of the primary DNA
sequence, we are still far from understanding the molecular events underlying phenotypic …
sequence, we are still far from understanding the molecular events underlying phenotypic …