Introduction Epidemiological studies demonstrated that cleaning work and frequent use of
cleaning products are risk factors for asthma. Laundry detergents have been reported to …

The immune system is responsible for defending an organism against the myriad of
microbial invaders it constantly confronts. It has become increasingly clear that the immune …

Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of
tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in …

In response to infections and irritants, the respiratory epithelium releases the alarmin
interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the …

From birth onward, the lungs are exposed to the external environment and therefore harbor
a complex immunological milieu to protect this organ from damage and infection. We …

The role of IL‐33/ST2 pathway in antitumor immunity is unclear. Using 4T1 breast cancer
model we demonstrate time‐dependent increase of endogenous IL‐33 at both the mRNA …

Allergic sensitization to inhaled antigens is common but poorly understood. Although lung
epithelial cells were initially merely regarded as a passive barrier impeding allergen …

Dietary fiber improves metabolic health, but host-encoded mechanisms for digesting fibrous
polysaccharides are unclear. In this work, we describe a mammalian adaptation to dietary …

Recent studies have highlighted a role for the alarmin interleukin (IL)-33 in CD4+ and CD8+
T cell activation and function, and have also revealed important distinctions. The IL-33 …

Chitin, a polysaccharide constituent of many allergens and parasites, initiates innate type 2
lung inflammation through incompletely defined pathways. We show that inhaled chitin …