Simple Summary An overwhelming percentage of deaths in solid tumors are caused by
treatment failure due to the disease's unresponsiveness when tumor cells tolerate treatment …

Distant metastasis remains a leading cause of mortality among patients with colorectal
cancer (CRC). Organotropism, referring to the propensity of metastasis to target specific …

Cancer stem cells (CSCs) are considered the roots of cancer metastasis and recurrence
(CSCs), due in part to their self‐renewal and therapy resistance properties. However, the …

Background This study aims to evaluate the efficacy and therapeutic mechanism of bufalin
on lung adenocarcinoma (LUAD) through a comprehensive strategy integrating network …

Cancer cells undergo a metabolic rewiring in order to fulfill the energy and biomass
requirements. Cysteine is a pivotal organic compound that contributes for cancer metabolic …

Glioblastoma (GBM) is the most lethal central nervous system (CNS) tumor, mainly due to its
high heterogeneity, invasiveness, and proliferation rate. These tumors remain a therapeutic …

Background: Cancer-associated thrombosis (CAT) and venous thromboembolism (VTE) are
frequent cancer-related complications associated with high mortality; thus, this urges the …

Cutaneous melanoma (CM) is the most aggressive skin cancer, showing globally increasing
incidence. Hereditary CM accounts for a significant percentage (5–15%) of all CM cases …

Metabolic remodeling is a critical skill of malignant cells, allowing their survival and spread.
The metabolic dynamics and adaptation capacity of cancer cells allow them to escape from …

Background Metabolic remodeling is crucial in carcinogenesis and cancer progression.
Oncogenic mutations may promote metabolic reprogramming in cancer cells to support their …