Apoptosis is now recognized as a normal feature in the development of the nervous system
and may also play a role in neurodegenerative diseases and aging. This phenomenon has …

Programmed cell death or apoptosis is broadly responsible for the normal homeostatic
removal of cells and has been increasingly implicated in mediating pathological cell loss in …

3‐Hydroxykynurenine (3‐HK) is a potential endogenous neurotoxin whose increased levels
have been described in several neurodegenerative disorders. Here, we characterized in …

Apoptosis of mouse neocortical neurons induced by serum deprivation or by staurosporine
was associated with an early enhancement of delayed rectifier (IK) current and loss of total …

Sympathetic neurons in culture die by apoptosis when deprived of nerve growth factor
(NGF). We used this model of programmed cell death to study the mechanisms that mediate …

Previous studies have shown that β-amyloid (Aβ) peptides are neurotoxic. Recent data
suggest that neurons undergoing Aβ-induced cell death exhibit characteristics that …

Cytokines are a heterogenous group of polypeptide mediators that have been associated
with activation of numerous functions, including the immune system and inflammatory …

Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral
nervous system and are crucial mediators of neuronal excitability. Importantly, these …

We examined the effects of various types of oxidative stress on cell survival and on
mitochondrial membrane potential (ΔΨm) in PC12 cells transfected with BCL‐2. Several …

Recent evidence indicates that the p53 tumor suppressor protein, and its related family
member, p73, play an essential role in regulating neuronal apoptosis in both the developing …