A spectral analysis approach was developed for detailed study of time‐resolved, dynamic
changes in vascular smooth muscle cell (VSMC) elasticity and adhesion to identify …

Interstitial flow is an important regulator of various cell behaviors both in vitro and in vivo, yet
the forces that fluid flow imposes on cells embedded in a 3D extracellular matrix (ECM), and …

Aims Vascular stiffness increases with age and independently predicts cardiovascular
disease risk. Epigenetic changes, including histone modifications, accumulate with age but …

In migrating cells, retrograde flow of the actin cytoskeleton is related to traction at adhesion
sites located at the base of the lamellipodium. The coupling between the moving …

The ability to measure dynamic structural changes within a cell under applied load is
essential for developing more accurate models of cell mechanics and mechanotransduction …

Aging induces a progressive decline in vasoconstrictor responses in central and peripheral
arteries. This study investigated the hypothesis that vascular smooth muscle (VSM) …

In vascular smooth muscle cells (VSMCs) integrin-mediated adhesion to extracellular matrix
(ECM) proteins play important roles in sustaining vascular tone and resistance. The main …

The malignant brain cancer glioblastoma multiforme (GBM) displays invasive growth
behaviors that are regulated by extracellular cues within the neural microenvironment. The …

Atomic Force Microscopy (AFM) is successfully used for the quantitative investigation of the
cellular mechanosensing of the microenvironment. To this purpose, several force …

Key points This study demonstrates rapid and dynamic changes in adhesion and cell
elasticity following agonist stimulation that culminate in a remodelled cytoskeleton in …