Joint profiling of chromatin accessibility and gene expression in individual cells provides an
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …

We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

Recent advances in single-cell technologies have enabled the characterization of
epigenomic heterogeneity at the cellular level. Computational methods for automatic cell …

Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and
glial cell types within the human brain. However, the regulatory programs governing cell …

The recovery of spinal cord injury (SCI) is closely associated with the obstruction of
oligodendrocyte progenitor cell (OPC) differentiation, which ultimately induces the inability to …

Most genetic variants associated with psychiatric disorders are located in noncoding regions
of the genome. To investigate their functional implications, we integrate epigenetic data from …

In oligodendrocytes of the vertebrate central nervous system a complex network of
transcriptional regulators is required to ensure correct and timely myelination of neuronal …

Originally approved by the US Food and Drug Administration (FDA) for its antihistamine
properties, clemastine can also promote white matter integrity and has shown promise in the …

Oligodendrogenesis in the human central nervous system has been observed mainly at the
second trimester of gestation, a much later developmental stage compared to …

We profile genome-wide histone 3 lysine 27 acetylation (H3K27ac) of 3 major brain cell
types from hippocampus and dorsolateral prefrontal cortex (dlPFC) of subjects with and …