Recent advances in miRNA delivery systems

I Dasgupta, A Chatterjee - Methods and protocols, 2021 - mdpi.com
MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that
are produced in a tissue and time-specific manner to orchestrate gene expression post …

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

[HTML][HTML] Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization

R Shi, Y Jin, S Zhao, H Yuan, J Shi, H Zhao - Biomedicine & …, 2022 - Elsevier
Diabetes mellitus is a major cause of blindness and chronic ulcers in the working age
population worldwide. Former research have found that differentially expressed circular …

Exosomes: Isolation, characterization, and biomedical applications

GN Alzhrani, ST Alanazi, SY Alsharif… - Cell Biology …, 2021 - Wiley Online Library
Exosomes are nano‐sized bioactive vesicles of 30–150 nm in diameter. They are secreted
by exocytosis of nearly all type of cells in to the extracellular fluid. Thereby, they can be …

[HTML][HTML] Extracellular vesicle activities regulating macrophage-and tissue-mediated injury and repair responses

Q Hu, CJ Lyon, JK Fletcher, W Tang, M Wan… - … Pharmaceutica Sinica B, 2021 - Elsevier
Macrophages are typically identified as classically activated (M1) macrophages and
alternatively activated (M2) macrophages, which respectively exhibit pro-and anti …

Dissecting the theranostic potential of exosomes in autoimmune disorders

VP Jayaseelan, P Arumugam - Cellular & molecular immunology, 2019 - nature.com
The biology of exosomes is a fascinating field of science that has attracted much attention
from clinical researchers due to the plethora of associated applications. These biological …

[HTML][HTML] Exosomes as drug delivery systems: endogenous nanovehicles for treatment of systemic lupus erythematosus

A Ortega, O Martinez-Arroyo, MJ Forner, R Cortes - Pharmaceutics, 2021 - mdpi.com
Exosomes, nanometer-sized lipid-bilayer-enclosed extracellular vesicles (EVs), have
attracted increasing attention due to their inherent ability to shuttle proteins, lipids and genes …

Emerging roles of exosomes in T1DM

H Pang, S Luo, Y Xiao, Y Xia, X Li, G Huang… - Frontiers in …, 2020 - frontiersin.org
Type 1 diabetes mellitus (T1DM) is a complex autoimmune disorder that mainly affects
children and adolescents. The elevated blood glucose level of patients with T1DM results …

Exosomes: a new horizon in modern medicine

A Deb, S Gupta, PB Mazumder - Life Sciences, 2021 - Elsevier
Exosomes are a type of extracellular vesicles belonging to endocytic origin. These vesicles
carry different biological cargo that play numerous physiological roles and is also indicative …

Ligand-displaying-exosomes using RNA nanotechnology for targeted delivery of multi-specific drugs for liver cancer regression

S Ellipilli, H Wang, DW Binzel, D Shu, P Guo - … , Biology and Medicine, 2023 - Elsevier
Liver cancer such as hepatocellular carcinoma (HCC) poorly responds to
chemotherapeutics as there are no effective means to deliver the drugs to liver cancer. Here …