Dissolution has become an indispensable tool to predict the in vivo performance of dosage
form, especially in recent times, because of the increasing complexity of new drugs …

It is our hypothesis that the presence of an absorptive sink for in-vitro dissolution
experiments is decisive to predict extent and duration of super-saturation of low soluble …

This article reviews the impacts on the in vivo prediction of oral bioavailability (BA) and
bioequivalence (BE) based on Biopharmaceutical classification systems (BCS) by the food …

The formulation developments and the in vivo assessment of Biopharmaceutical
Classification System (BCS) class II drugs are challenging due to their low solubility and …

An in vitro methodology for simulating the change in the pH and composition of
gastrointestinal fluid associated with the transition of orally administered drugs from the …

Combined dissolution and permeation systems are designed to simultaneously assess the
dissolution of a pharmaceutical dosage form and the permeation of dissolved drugs …

The objective of this study was to develop a novel open-mode two-compartment system
dissolution apparatus to simulate the dissolution and absorption of poorly soluble drugs and …

The objective of this study was to investigate the implications of changing dissolution
parameters, including pH ramp time, absence and presence of simulated intestinal fluid …

Ispitivanje brzine rastvaranja lekovite supstance iz preparata prepoznato je kao
najznačajnija in vitro metoda u biofarmaceutskoj karakterizaciji lekova. Adekvatno …