The role of NLRP3 inflammasome in cerebrovascular diseases pathology and possible therapeutic targets

R Bai, Y Lang, J Shao, Y Deng, R Refuhati… - ASN neuro, 2021 - journals.sagepub.com
Cerebrovascular diseases are pathological conditions involving impaired blood flow in the
brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid …

Natural products modulate cell apoptosis: A promising way for the treatment of ulcerative colitis

C Liu, Y Zeng, Y Wen, X Huang, Y Liu - Frontiers in pharmacology, 2022 - frontiersin.org
Ulcerative colitis (UC) is a chronic inflammatory bowel disease impacting patients' quality of
life and imposing heavy societal and economic burdens. Apoptosis of intestinal epithelial …

Caffeic acid supplement alleviates colonic inflammation and oxidative stress potentially through improved gut microbiota community in mice

F Wan, R Zhong, M Wang, Y Zhou, Y Chen… - Frontiers in …, 2021 - frontiersin.org
Caffeic acid (CA) is one of the major phenolic acids of coffee with multiple biological
activities. Our previous study found that 500 mg/kg of chlorogenic acid (CGA) had the …

Thyme (Thymus vulgaris L.) polyphenols ameliorate DSS-induced ulcerative colitis of mice by mitigating intestinal barrier damage, regulating gut microbiota, and …

Z Zhou, W He, H Tian, P Zhan, J Liu - Food & function, 2023 - pubs.rsc.org
Thyme (Thymus vulgaris L.) is an important medicinal and edible homologous plant, and the
composition and bioactivity of its polyphenol extracts have attracted widespread attention …

Ferulic acid ameliorates ulcerative colitis in a rat model via the inhibition of two LPS-TLR4-NF-κB and NF-κB-INOS-NO signaling pathways and thus alleviating the …

M Ghasemi-Dehnoo, H Amini-Khoei, Z Lorigooini… - …, 2023 - Springer
Introduction Ulcerative colitis is a chronic inflammation of the colon. However, the common
treatment for it is accompanied by many complications. Therefore, the present study was …

Supplementation With Chinese Medicinal Plant Extracts From Lonicera hypoglauca and Scutellaria baicalensis Mitigates Colonic Inflammation by Regulating …

F Wan, M Wang, R Zhong, L Chen, H Han… - Frontiers in cellular …, 2022 - frontiersin.org
Colitis, a chronic inflammatory bowel disease, is characterized by bloody diarrhea and
inflammation in the colon. Lonicera hypoglauca (“Shanyinhua” in Chinese) and Scutellaria …

Discoidin domain receptor 1 (DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis

X Li, Q Li, B Xiong, H Chen, X Wang, D Zhang - Pharmacological Research, 2022 - Elsevier
Background and aims Discoidin domain receptor 1 (DDR1) encodes a receptor tyrosine
kinase involved in multiple physiological and pathological processes. DDR1 is expressed in …

[HTML][HTML] Flavonoids and saponins: What have we got or missed?

X Wang, Y Ma, Q Xu, AN Shikov, ON Pozharitskaya… - Phytomedicine, 2023 - Elsevier
Background Flavonoids and saponins are important bioactive compounds that have
attracted wide research interests. This review aims to summarise the state of the art of the …

Epigallocatechin gallate alleviates staphylococcal enterotoxin a-induced intestinal barrier damage by regulating gut microbiota and inhibiting the TLR4-NF-κB/MAPKs …

C Liu, J Liu, W Wang, M Yang, K Chi… - Journal of Agricultural …, 2023 - ACS Publications
Natural phytochemicals have attracted increasing attention because of their promising ability
to tackle bacteriotoxin-induced public safety concerns. However, it is unclear how natural …

[HTML][HTML] Arjunolic acid protects the intestinal epithelial barrier, ameliorating Crohn's disease-like colitis by restoring gut microbiota composition and inactivating TLR4 …

Z Zhang, L Zuo, X Song, L Wang, Y Zhang, Y Cheng… - Phytomedicine, 2024 - Elsevier
Abstract Background and Aims Crohn's disease (CD) is characterized by an overabundance
of epithelial cell death and an imbalance in microflora, both of which contribute to the …