TRANSPLANTATION has evolved greatly over the past two decades, from a desperate,
experimental procedure with an expected l-year survival rate of only 20% in 1968',* to a …

Background Apoptosis is a distinct form of programmed cell death characterized by
activation of endonucleases that cleave nuclear DNA, condensation and fragmentation of …

Lynne Warner Stevenson, MD, graduated from Princeton University and received her MD
from Stanford University Medical School. She completed her residency and cardioiogy …

Vascular endothelial cells act as antigen-presenting cells in the lung allograft and stimulate
alloreactive host lymphocytes. Activated lymphocytes and cytokines can induce expression …

Over the last 10 years, our knowledge of immunologically mediated processes involving the
myocardium appears to have made quantum leaps. New and important disease entities …

Background Immunologic mechanisms that mediate myocardial cell injury during rejection
are not fully understood. We therefore investigated whether cells that infiltrate rejecting …

The nature of the impaired cardiac performance seen in septic shock, acute myocarditis,
dilated cardiomyo‐pathy, heart transplant rejection and immunotherapy cardiomyopathy is …

The negative inotropism, myocardial dilatation and cytotoxicity in inflammatory heart
disorders may be due to increased generation of nitric oxide (NO) by immunological …

To determine the incidence and morphologic features of acute vascular rejection (AVR) in
cardiac transplant patients who have not received OKT3 induction therapy, we performed …

Accelerated atherosclerosis remains the single most important obstacle limiting the long-
term success of cardiac transplantation. It occurs to different degrees in all long-term …