Quantity, quality, and lifespan are 3 important factors in the physiology, pathology, and
transfusion of human blood platelets. The aim of this review is to discuss the proteolytic …

The platelet-activating collagen receptor GPVI represents the focus of clinical trials as an
antiplatelet target for arterial thrombosis, and soluble GPVI is a plasma biomarker for several …

Glenzocimab (ACT017) is a humanized monoclonal antigen‐binding fragment (Fab)
directed against the human platelet glycoprotein VI, a key receptor for collagen and fibrin …

At the clinical level, recent studies reveal the link between coagulation and other
pathophysiological processes, including platelet activation, inflammation, cancer, the …

Background and Purpose—CLEC-2 (C-type lectin-like receptor 2) is a C-type lectin receptor
highly expressed on platelets with the prominent involvement in platelet activation, which …

Proteolytic shedding of the extracellular ectodomain of platelet receptors provides a key
mechanism for irreversible loss of ligand-binding capacity, and for regulating platelet …

Platelets are anucleate cells known for their essential function in hemostasis and formation
of thrombi under pathologic conditions. In recent years, strong evidence emerged …

Platelet adhesion and activation is fundamental to the formation of a hemostatic response to
limit loss of blood and instigate wound repair to seal a site of vascular injury. The process of …

Background and Aims Glycoprotein VI (GPVI) is the major platelet-specific collagen receptor.
GPVI shedding with generation of soluble GPVI (sGPVI) is an endogenous feedback …

Arterial thrombosis is in part contributed by excessive platelet aggregation, which can lead
to blood clotting and subsequent heart attack and stroke. Platelets are sensitive to the …