Developmental changes in children can affect the disposition and clinical effects of a drug,
indicating that scaling an adult dose simply down per linear weight can potentially lead to …

Caffeine citrate is the drug of choice for the pharmacological treatment of apnea of
prematurity. Factors such as maturity and genetic variation contribute to the interindividual …

Concerns over gestational effects on the disposition of drugs has highlighted the need for a
better understanding of drug distribution and elimination during pregnancy. This study …

Perinatal pharmacology is influenced by a myriad of physiological variables that are
changing dynamically. The influence of these covariates has not been assessed …

Each year, infections caused around the 25% of neonatal deaths. Early empirical treatments
help to reduce this mortality, although optimized dosing regimens are still lacking. The aims …

Background Developmental physiology can alter pharmacotherapy in preterm populations.
Because of ethical and clinical constraints in studying this vulnerable age group …

Physiologically based pharmacokinetic (PBPK) modeling can be an attractive tool to
increase the evidence base of pediatric drug dosing recommendations by making optimal …

Abstract Background and Objective Pethidine (meperidine) can decrease labor pain-
associated mother's hyperventilation and high cortisol-induced newborn complications …

Due to complex maturational and physiological changes that characterize neonates and
affect their response to pharmacological treatments, neonatal pharmacology is different from …

In premature infants, effective and safe drug therapy depends on optimal dose selection and
requires a thorough understanding of the underlying disease (s) of these fragile infants as …