Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …

Stem cell-based therapy has been one of the best documented approaches in regenerative
medicine, promising cures for a multitude of diseases and disorders. However, the ex vivo …

Growth factors in serum-free conditioned media from human bone marrow-derived
mesenchymal stem cells (MSC-CM) are known to be effective in bone regeneration …

A leading strategy in tissue engineering is the design of biomimetic scaffolds that stimulate
the body's repair mechanisms through the recruitment of endogenous stem cells to sites of …

Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue
against the detrimental effects of acute ischemia-reperfusion injury (IRI). It describes an …

Upon secretion, transforming growth factor β (TGFβ) is maintained in a sequestered state in
extracellular matrix as a latent form. The latent TGFβ is considered as a molecular sensor …

Bone marrow (BM)-derived stem and progenitor cell functions including self-renewal,
differentiation, survival, migration, proliferation, and mobilization are regulated by unique …

Translational medicine is an evolutional concept that encompasses the rapid translation of
basic research for use in clinical disease diagnosis, prevention and treatment. It follows the …

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The use of stem
cells to improve recovery of the injured heart after myocardial infarction (MI) is an important …

To coordinate specialized organs, inter-tissue communication appeared during evolution.
Consequently, individual organs communicate their states via a vast interorgan …