Galanin peptide family as a modulating target for contribution to metabolic syndrome

P Fang, M Yu, M Shi, Z Zhang, Y Sui, L Guo… - General and comparative …, 2012 - Elsevier
Metabolic syndrome (MetS) is defined as abdominal central obesity, atherogenic
dyslipidemia, insulin resistance, glucose intolerance and hypertension. The rapid increasing …

Neuropeptide galanin and its effects on metabolic and reproductive disturbances in female rats with estradiol valerate (EV)-induced polycystic ovary syndrome (PCOS …

F Azin, H Khazali - Neuropeptides, 2020 - Elsevier
A functional role of the neuropeptide galanin, executed through the three G-protein coupled
receptor subtypes GAL₁₋ ₃, has been demonstrated in many biological systems and …

Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: implications for obesity …

S Davidson, M Lear, L Shanley, B Hing… - …, 2011 - nature.com
The expression of the galanin gene (GAL) in the paraventricular nucleus (PVN) and in the
amygdala of higher vertebrates suggests the requirement for highly conserved, but …

Galanin antagonist increases insulin resistance by reducing glucose transporter 4 effect in adipocytes of rats

L Guo, M Shi, L Zhang, G Li, L Zhang, H Shao… - General and …, 2011 - Elsevier
Seeing that galanin increases animal body weight on the conditions of inhibiting insulin
secretion and animals with metabolic disorder of galanin easily suffer from diabetes, we …

Exercise-induced galanin release facilitated GLUT4 translocation in adipocytes of type 2 diabetic rats

Y Liang, S Sheng, P Fang, Y Ma, J Li, Q Shi… - Pharmacology …, 2012 - Elsevier
Although galanin has been shown to increase insulin sensitivity in skeletal muscle of rats,
there is no literature available about the effect of galanin on Glucose Transporter 4 (GLUT4) …

Endogenous galanin as a novel biomarker to predict gestational diabetes mellitus

Z Zhang, C Gu, P Fang, M Shi, Y Wang, Y Peng, P Bo… - Peptides, 2014 - Elsevier
Although a significantly higher level of plasma galanin was found in patients with gestational
diabetes mellitus (GDM) in our previous study, it is unknown whether plasma galanin is …

Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats

P Fang, B He, M Yu, M Shi, Y Zhu, Z Zhang… - Biochemical …, 2018 - Elsevier
Although recent results of our and other studies have showed that galanin (GAL) is an
antidiabetic and anti-inflammatory neuropeptide, the molecular mechanism how central GAL …

Exogenous galanin alleviates hepatic steatosis by promoting autophagy via the AMPK-mTOR pathway

S Zhu, S Wang, T Luo - Archives of Biochemistry and Biophysics, 2023 - Elsevier
Defective autophagy-induced intracellular lipid degradation is causally associated with non-
alcoholic fatty liver disease (NAFLD) development. Therefore, agents that can restore …

[PDF][PDF] Thermoregulation, energy balance, regulatory peptides: recent developments

M Szekely, E Petervari, M Balasko - Front Biosci (Schol Ed), 2010 - article.imrpress.com
[Frontiers in Bioscience S2, 1009-1046, June 1, 2010] 1009 Thermoregulation, energy balance,
regulatory peptides: recent develop Page 1 [Frontiers in Bioscience S2, 1009-1046, June 1 …

Intracerebroventricular administration of galanin antagonist sustains insulin resistance in adipocytes of type 2 diabetic trained rats

Z Zhang, S Sheng, L Guo, G Li, L Zhang… - Molecular and cellular …, 2012 - Elsevier
The aim of this study is to investigate whether galanin (GAL) central receptors are involved
in regulation of insulin resistance. To test it, a GAL antagonist, M35 was …