Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …

Post-acute COVID-19 sequelae, commonly known as long COVID, encompasses a range of
systemic symptoms experienced by a significant number of COVID-19 survivors. The …

A robust and heterogenous secretory phenotype is a core feature of most senescent cells. In
addition to mediators of age‐related pathology, components of the senescence associated …

Dementia caregiving has been linked to multiple health risks, including infectious illness,
depression, anxiety, immune dysregulation, weakened vaccine responses, slow wound …

Calorie restriction (CR) with adequate nutrient intake is a potential geroprotective
intervention. To advance this concept in humans, we tested the hypothesis that moderate …

Studies in mice and cross-sectional studies in humans support the premise that cellular
senescence is a contributing mechanism to age-associated deficits in physical function. We …

Simple Summary Idiopathic pulmonary fibrosis (IPF) presents a significant challenge.
Despite extensive research, our understanding of its underlying causes remains limited. One …

Aging and cellular senescence are increasingly recognized as key contributors to
pulmonary fibrosis. However, our understanding in the context of scleroderma-associated …

Right heart failure is the leading cause of death in pulmonary hypertension (PH), and
echocardiography is a commonly used tool for evaluating the risk hierarchy of PH. However …

Greater insights into biological mechanisms (hallmarks) of aging, their associations with
aging-related diseases and disabilities, and early evidence that they can be modified by …