Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention
Z Zhang, M Chen, W Zhan, Y Chen, T Wang… - Cell Death …, 2023 - nature.com
Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel
(ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout …
(ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout …
TRPV1 Channels in the Central Nervous System as Drug Targets
LA Chahl - Pharmaceuticals, 2024 - mdpi.com
TRPV1 channels are polymodal cation channels located predominantly on primary afferent
neurons that are activated by inflammatory mediators, capsaicin (the active component in …
neurons that are activated by inflammatory mediators, capsaicin (the active component in …
[HTML][HTML] Ammonium chloride-induced hypothermia is attenuated by transient receptor potential channel vanilloid-1, but augmented by ankyrin-1 in rodents
Z Rumbus, L Kelava, B Gardos, K Klonfar, P Keringer… - Life Sciences, 2024 - Elsevier
Aims Systemic administration of ammonium chloride (NH 4 Cl), an acidifying agent used in
human patients and experimental conditions, causes hypothermia in mice, however, the …
human patients and experimental conditions, causes hypothermia in mice, however, the …
Selection of preferred thermal environment and cold-avoidance responses in rats rely on signals transduced by the dorsal portion of the lateral funiculus of the spinal …
Thermoregulatory behaviors are powerful effectors for core body temperature (Tc)
regulation. We evaluated the involvement of afferent fibers ascending through the dorsal …
regulation. We evaluated the involvement of afferent fibers ascending through the dorsal …
From capsaicin to TRPV1: The “hot” legacy of János Szolcsányi
Capsaicin represents an area of sensory pharmacology intimately familiar to the estimated
quarter of the world's population who consume hot pepper on a daily basis. Hot pepper is …
quarter of the world's population who consume hot pepper on a daily basis. Hot pepper is …