People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …

Anti-epileptic drugs (AEDs) are an important group of drugs of several generations, ranging
from the oldest phenobarbital (1912) to the most recent cenobamate (2019). Cannabidiol …

Here, we describe the synthesis and anticonvulsant activity of thiazole-bearing hybrids
based on 2-imino-4-thiazolidinone and 2, 4-dioxothiazolidine-5-carboxylic acid cores. The …

Background: The design and development of prodrugs is the most common and effective
strategy to overcome pharmacokinetic and pharmacodynamic drawbacks of active drugs. A …

The propagation of epileptiform events is a highly interesting phenomenon from the
pathophysiological point of view, as it involves several mechanisms of recruitment of neural …

Introduction of acetoxy groups to organic molecules is important for the preparation of many
active ingredients and synthetic intermediates. A commonly used and attractive strategy is …

Background: Adverse effects of antiseizure medications (ASMs) remain one of the major
causes of non-adherence. Cosmetic side effects (CSEs) are among the most commonly …

Selecting the most appropriate antiepileptic drug (AED) or combination of drugs for each
patient and identifying the most suitable therapeutic regimen for their needs is increasingly …

Background Carbamazepine (CBZ), oxcarbazepine (OXC), and eslicarbazepine (ESL)
acetate belong to the dibenzazepine family. In this context, the aim of this literature review is …

The review presents data from the last few years on bioanalytical methods used in
therapeutic drug monitoring (TDM) of the 1st–3rd generation and the newest antiepileptic …