Cerebral plasticity: Windows of opportunity in the developing brain
Background Neuroplasticity refers to the inherently dynamic biological capacity of the central
nervous system (CNS) to undergo maturation, change structurally and functionally in …
nervous system (CNS) to undergo maturation, change structurally and functionally in …
Dendritic structural plasticity and neuropsychiatric disease
MP Forrest, E Parnell, P Penzes - Nature Reviews Neuroscience, 2018 - nature.com
The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …
and refined throughout development and into adulthood. Evidence from human and animal …
mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity
Postmortem studies have revealed increased density of excitatory synapses in the brains of
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …
Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models
V Martínez‐Cerdeño - Developmental neurobiology, 2017 - Wiley Online Library
Dendrites and spines are the main neuronal structures receiving input from other neurons
and glial cells. Dendritic and spine number, size, and morphology are some of the crucial …
and glial cells. Dendritic and spine number, size, and morphology are some of the crucial …
[HTML][HTML] Rescuing over-activated microglia restores cognitive performance in juvenile animals of the Dp (16) mouse model of Down syndrome
Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive
functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is …
functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is …
Modeling the interplay between neurons and astrocytes in autism using human induced pluripotent stem cells
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with unclear
etiology and imprecise genetic causes. The main goal of this work was to investigate …
etiology and imprecise genetic causes. The main goal of this work was to investigate …
[HTML][HTML] Autism: Will vitamin D supplementation during pregnancy and early childhood reduce the recurrence rate of autism in newborn siblings?
G Stubbs, K Henley, J Green - Medical hypotheses, 2016 - Elsevier
Background Vitamin D deficiency is widespread in the world including the vulnerable group
of pregnant women. Vitamin D deficiency during pregnancy is hypothesized to contribute to …
of pregnant women. Vitamin D deficiency during pregnancy is hypothesized to contribute to …
Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl
CpG binding protein 2 (MECP2) gene. There are currently no approved treatments for RTT …
CpG binding protein 2 (MECP2) gene. There are currently no approved treatments for RTT …
Autism and schizophrenia-associated CYFIP1 regulates the balance of synaptic excitation and inhibition
Altered excitatory/inhibitory (E/I) balance is implicated in neuropsychiatric and
neurodevelopmental disorders, but the underlying genetic etiology remains poorly …
neurodevelopmental disorders, but the underlying genetic etiology remains poorly …