Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions
that results in structural and functional remodeling leading to subsequent impairment of …

Diabetes is a major risk factor for cardiovascular diseases, including diabetic
cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular …

Background: CD4+ T cells temporally transition from protective to pathological during
ischemic heart failure (HF; 8 weeks postmyocardial infarction). Cellular mechanisms …

Arachidonate 5-lipoxygenase (ALOX5)-derived leukotrienes are primary signals of leukocyte
activation and inflammation in response to ischemic cardiac injury (MI; myocardial …

Myocardial infarction (MI) is defined as evidence of myocardial necrosis consistent with
prolonged ischemia. In response to MI, the myocardium undergoes a series of wound …

Myocardial infarction is a major cause of morbidity and mortality worldwide. Due to poor
inherent regeneration of the adult mammalian myocardium and challenges with effective …

Heart failure (HF) is a leading cause of death and repeated hospitalizations and often
involves cardiac mitochondrial dysfunction. However, the underlying mechanisms largely …

Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted,
leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of …

Background Macrophage infiltration and polarization are integral to the progression of heart
failure and cardiac fibrosis after ischemia/reperfusion (IR). Interleukin 34 (IL-34) is an …

Sex is a key risk factor for many types of cardiovascular disease. It is imperative to
understand the mechanisms underlying sex differences to devise optimal preventive and …