Patients with chronic kidney disease have an increased cardiovascular morbidity and
mortality. It has been recognized that the traditional cardiovascular risk factors could only …

Endothelial nitric oxide synthase (eNOS) serves as a critical enzyme in maintaining vascular
pressure by producing nitric oxide (NO); hence, it has a crucial role in the regulation of …

Oxidative stress (OS) and excessive reactive oxygen species (ROS) production have been
implicated in many neurological pathologies, including acute seizures and epilepsy. Seizure …

Markers of increased oxidative stress are known to be elevated following acute myocardial
infarction and in the context of chronic left ventricular hypertrophy or heart failure, and their …

The multifunctional Ca2+-and calmodulin-dependent protein kinase II (CaMKII) is now
recognized to play a central role in pathological events in the cardiovascular system. CaMKII …

Oxidative stress has been increasingly linked to the high incidence of cardiovascular events
in patients with chronic kidney disease (CKD), especially as traditional cardiovascular risk …

Background—Heart failure with preserved ejection fraction is 1 consequence of
hypertension and is caused by impaired cardiac diastolic relaxation. Nitric oxide (NO) is a …

Background—An altered nitric oxide–redox balance has been implicated in the
pathogenesis of atrial fibrillation (AF). Statins inhibit NOX2-NADPH oxidases and prevent …

Cardiac hypertrophy (CH) is an adaptive response of the heart to pressure overload. It is a
common pathological feature in the natural course of some major cardiovascular diseases …

There is increasing evidence that upregulation of arginase contributes to impaired
endothelial function in aging. In this study, we demonstrate that arginase upregulation leads …