It is increasingly evident that redox-dependent modifications in cellular proteins and
signaling pathways (or redox signaling) play important roles in many aspects of cardiac …

Oxidative stress, defined as the excess production of reactive oxygen species (ROS) relative
to antioxidant defense, plays a significant role in the development of cardiovascular …

Trimetazidine (TMZ) is used successfully for treatment of ischemic cardiomyopathy, however
its therapeutic potential in heart failure (HF) remains to be established. While the …

Cardiovascular disease (CVD) is the first leading cause of death globally. Nitric oxide (NO)
is an important signaling molecule that mediates diverse processes in the cardiovascular …

Cyclic nucleotide phosphodiesterases (PDEs) form an 11-member superfamily comprising
100 different isoforms that regulate the second messengers cyclic adenosine or guanosine …

Aims Cardiac fibrosis contributes to the transition from compensated ventricular hypertrophy
to heart failure, which can be promoted by connective tissue growth factor (CTGF) …

The pathogenesis of many cardiovascular diseases is associated with reduced nitric oxide
(NO) bioavailability and/or increased endothelial NO synthase (eNOS)-dependent …

Increases in NADPH oxidase activity, oxidative stress, and myocyte apoptosis coexist in
failing hearts. In cardiac myocytes in vitro inhibition of NADPH oxidase reduces apoptosis. In …

Diabetic cardiomyopathy refers to the manifestations in the heart as a result of altered
glucose homeostasis, reflected as fibrosis, cellular hypertrophy, increased oxidative stress …

There is not too much success in the antioxidant treatment of heart deceases in humans.
However a new approach is now developed that suggests that depending on their structures …