Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and
behavior have steadily increased over the last two decades, stimulating considerable …

Tailoring formulations for intranasal nose-to-brain delivery: a review on architecture, physico-chemical characteristics and mucociliary clearance of the nasal olfactory …

S Gänger, K Schindowski - Pharmaceutics, 2018 - mdpi.com
The blood-brain barrier and the blood-cerebrospinal fluid barrier are major obstacles in
central nervous system (CNS) drug delivery, since they block most molecules from entering …

Bioeffects of inhaled nanoplastics on neurons and alteration of animal behaviors through deposition in the brain

X Liu, Y Zhao, J Dou, Q Hou, J Cheng, X Jiang - Nano Letters, 2022 - ACS Publications
The potential toxicity of nanoplastics on plants has previously been illustrated, but whether
nanoplastics could cause neurotoxicity, especially to higher animals, remains unclear. We …

Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development

GF Koob - Pharmacological Reviews, 2021 - ASPET
Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …

Social skills deficits in autism spectrum disorder: potential biological origins and progress in developing therapeutic agents

RE Frye - CNS drugs, 2018 - Springer
Autism spectrum disorder is defined by two core symptoms: a deficit in social communication
and the presence of repetitive behaviors and/or restricted interests. Currently, there is no US …

Nose-to-brain delivery

Z Wang, G Xiong, WC Tsang, AG Schätzlein… - … of Pharmacology and …, 2019 - ASPET
The global prevalence of neurologic disorders is rising, and yet we are still unable to deliver
most drug molecules, in therapeutic quantities, to the brain. The blood brain barrier consists …

Intranasal delivery of nanoformulations: a potential way of treatment for neurological disorders

SU Islam, A Shehzad, MB Ahmed, YS Lee - Molecules, 2020 - mdpi.com
Although the global prevalence of neurological disorders such as Parkinson's disease,
Alzheimer's disease, glioblastoma, epilepsy, and multiple sclerosis is steadily increasing …

Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice

Y Yamamoto, M Liang, S Munesue, K Deguchi… - Communications …, 2019 - nature.com
Oxytocin sets the stage for childbirth by initiating uterine contractions, lactation and maternal
bonding behaviours. Mice lacking secreted oxcytocin (Oxt−/−, Cd38−/−) or its receptor …

Prolactin and oxytocin: potential targets for migraine treatment

AK Szewczyk, S Ulutas, T Aktürk, L Al-Hassany… - The Journal of …, 2023 - Springer
Migraine is a severe neurovascular disorder of which the pathophysiology is not yet fully
understood. Besides the role of inflammatory mediators that interact with the …

The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis

EA Lawson, PK Olszewski, A Weller… - Journal of …, 2020 - Wiley Online Library
Obesity and its associated complications have reached epidemic proportions in the USA
and also worldwide, highlighting the need for new and more effective treatments. Although …