White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small
vessel disease, and can easily be detected on MRI. Over the past three decades, research …

Background Cerebral small vessel disease, a common cause of vascular dementia, is often
considered clinically silent before dementia or stroke become apparent. However, some …

A 'frontal variant of Alzheimer's disease'has been described in patients with predominant
behavioural or dysexecutive deficits caused by Alzheimer's disease pathology. The …

Introduction Apathy is common in neurocognitive disorders (NCD) but NCD‐specific
diagnostic criteria are needed. Methods The International Society for CNS Clinical Trials …

Small vessel disease is a stroke subtype characterized by pathology of the small perforating
arteries, which supply the sub-cortical structures of the brain. Small vessel disease is …

Subcortical small-vessel disease (SSVD) is a disorder well characterized from the clinical,
imaging, and neuropathological viewpoints. SSVD is considered the most prevalent …

Background: Cerebral small vessel disease (SVD) is a common cause of stroke, mild
cognitive impairment, dementia and physical impairments. Differences in SVD incidence or …

Introduction This systematic review synthesizes current evidence for associations between
cortical amyloid β, visualized on amyloid positron emission tomography imaging, and white …

Patients with small vessel cerebrovascular disease frequently suffer from apathy, a
debilitating neuropsychiatric syndrome, the underlying mechanisms of which remain to be …

Dementia is a global growing concern, affecting over 35 million people with a global
economic impact of over $604 billion US. With an ageing population the number of people …