Dealing with the foreign‐body response to implanted biomaterials: strategies and applications of new materials

D Zhang, Q Chen, C Shi, M Chen, K Ma… - Advanced Functional …, 2021 - Wiley Online Library
Foreign‐body response caused by implanted biomaterials seriously impedes the function of
implants and is a major obstacle to the development of implantable biomaterials and …

Biocompatibility, biodegradation and biomedical applications of poly (lactic acid)/poly (lactic-co-glycolic acid) micro and nanoparticles

EM Elmowafy, M Tiboni, ME Soliman - Journal of Pharmaceutical …, 2019 - Springer
Background Poly (lactic acid)(PLA) and poly (lactic-co-glycolic acid)(PLGA) are among the
well-documented FDA-approved polymers used for the preparation of safe and effective …

Domesticating the foreign body response: Recent advances and applications

O Veiseh, AJ Vegas - Advanced drug delivery reviews, 2019 - Elsevier
The foreign body response is an immunological process that leads to the rejection of
implanted devices and presents a fundamental challenge to their performance, durability …

Biomaterials/tissue interactions: possible solutions to overcome foreign body response

JM Morais, F Papadimitrakopoulos, DJ Burgess - The AAPS journal, 2010 - Springer
In recent years, a variety of biomaterial implantable devices has been developed. Of
particular significance to pharmaceutical sciences is the progress made on the development …

The foreign body response demystified

Y Chandorkar, RK, B Basu - ACS Biomaterials Science & …, 2018 - ACS Publications
The human body is endowed with an uncanny ability to distinguish self from foreign. The
implantation of a foreign object inside a mammalian host activates complex signaling …

The foreign body response: at the interface of surgery and bioengineering

MR Major, VW Wong, ER Nelson… - Plastic and …, 2015 - journals.lww.com
Background: The surgical implantation of materials and devices has dramatically increased
over the past decade. This trend is expected to continue with the broadening application of …

Biomechanics of the sensor-tissue interface—effects of motion, pressure, and design on sensor performance and the foreign body response—part I: theoretical …

KL Helton, BD Ratner… - Journal of diabetes …, 2011 - journals.sagepub.com
The importance of biomechanics in glucose sensor function has been largely overlooked.
This article is the first part of a two-part review in which we look beyond commonly …

Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform

W Whyte, D Goswami, SX Wang, Y Fan… - Nature …, 2022 - nature.com
Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes
molecular transport and is detrimental to the long-term efficacy of implantable drug delivery …

Highly stable silver nanoparticles containing guar gum modified dual network hydrogel for catalytic and biomedical applications

R Deka, S Sarma, P Patar, P Gogoi, JK Sarmah - Carbohydrate polymers, 2020 - Elsevier
Although many preparation methods have been reported till date, it is still a great challenge
to prepare silver nanoparticles (AgNPs) that simultaneously possess high stability and …

Foreign body reaction to subcutaneous implants

M Kastellorizios, N Tipnis, DJ Burgess - Immune Responses to Biosurfaces …, 2015 - Springer
Subcutaneously implanted materials trigger the host's innate immune system, resulting in
the foreign body reaction. This reaction consists of protein adsorption on the implant surface …