Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

The occurrence of protein tyrosine nitration under disease conditions is now firmly
established and represents a shift from the signal transducing physiological actions of• NO …

Peroxynitrite, the product of the fast reaction between nitric oxide (• NO) and superoxide O
2•− radicals, is an oxidizing and nitrating agent which is able to traverse biological …

Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …

The transduction of cellular signals occurs through the modification of target molecules. Most
of these modifications are transitory, thus the signal transduction pathways can be tightly …

Protein tyrosine nitration (PTN) is a post-translational modification occurring under the action
of a nitrating agent. Tyrosine is modified in the 3-position of the phenolic ring through the …

Reactive oxygen species (ROS), either directly or via the formation of lipid peroxidation
products, such as 4-hydroxy-2-nonenal, acrolein and F2-isoprostanes, may play a role in …

Covalent amino acid modification significantly expands protein functional capability in
regulating biological processes. Tyrosine residues can undergo phosphorylation, sulfation …