COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …

Alzheimer's disease (AD) is a neurodegenerative old age disease that is complex,
multifactorial, unalterable, and progressive in nature. The currently approved therapy …

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

Sarcopenia is an important public health problem, characterized by age-related loss of
muscle mass and muscle function. It is a precursor of physical frailty, mobility limitation, and …

The renin–angiotensin system (RAS) was initially considered to be part of the endocrine
system regulating water and electrolyte balance, systemic vascular resistance, blood …

Research indicates that after advanced age, the major risk factor for late-onset Alzheimer's
disease is female sex. Out of every three AD patients, two are females with postmenopausal …

Mid-life hypertension and cerebrovascular dysfunction are associated with increased risk of
later life dementia, including Alzheimer's disease (AD). The classical renin–angiotensin …

Aging is the greatest risk factor for most diseases including cancer, cardiovascular disorders,
and neurodegenerative disease. There is emerging evidence that interventions that improve …

Genome-wide association studies (GWASs) have discovered numerous risk genes for
Alzheimer's disease (AD), but how these genes confer AD risk is challenging to decipher. To …

All over the world, metabolic syndrome constitutes severe health problems. Multiple factors
have been reported in the pathogenesis of metabolic syndrome. Metabolic disorders result …