Activation of the endonuclease that defines mRNA 3′ ends requires incorporation into an 8-subunit core cleavage and polyadenylation factor complex
Cleavage and polyadenylation factor (CPF/CPSF) is a multi-protein complex essential for
formation of eukaryotic mRNA 3ʹ ends. CPF cleaves pre-mRNAs at a specific site and adds …
formation of eukaryotic mRNA 3ʹ ends. CPF cleaves pre-mRNAs at a specific site and adds …
One, two, three, four! How multiple RRMs read the genome sequence
RRM-containing proteins are involved in most of the RNA metabolism steps. Their functions
are closely related to their mode of RNA recognition, which has been studied by structural …
are closely related to their mode of RNA recognition, which has been studied by structural …
[HTML][HTML] Nuclear mRNA metabolism drives selective basket assembly on a subset of nuclear pore complexes in budding yeast
To determine which transcripts should reach the cytoplasm for translation, eukaryotic cells
have established mechanisms to regulate selective mRNA export through the nuclear pore …
have established mechanisms to regulate selective mRNA export through the nuclear pore …
Paf1 has distinct roles in transcription elongation and differential transcript fate
RNA polymerase II (Pol2) movement through chromatin and the co-transcriptional
processing and fate of nascent transcripts is coordinated by transcription elongation factors …
processing and fate of nascent transcripts is coordinated by transcription elongation factors …
Widespread transcriptional readthrough caused by Nab2 depletion leads to chimeric transcripts with retained introns
Nascent RNA sequencing has revealed that pre-mRNA splicing can occur shortly after
introns emerge from RNA polymerase II (RNA Pol II). Differences in co-transcriptional …
introns emerge from RNA polymerase II (RNA Pol II). Differences in co-transcriptional …
Bayesian Markov models consistently outperform PWMs at predicting motifs in nucleotide sequences
M Siebert, J Söding - Nucleic acids research, 2016 - academic.oup.com
Position weight matrices (PWMs) are the standard model for DNA and RNA regulatory
motifs. In PWMs nucleotide probabilities are independent of nucleotides at other positions …
motifs. In PWMs nucleotide probabilities are independent of nucleotides at other positions …
Large scale RNA-binding proteins/LncRNAs interaction analysis to uncover lncRNA nuclear localization mechanisms
Long non-coding RNAs (lncRNAs) are key regulators of major biological processes and
their functional modes are dictated by their subcellular localization. Relative nuclear …
their functional modes are dictated by their subcellular localization. Relative nuclear …
Writing a wrong: coupled RNA polymerase II transcription and RNA quality control
SA Peck, KD Hughes, JF Victorino… - Wiley Interdisciplinary …, 2019 - Wiley Online Library
Processing and maturation of precursor RNA species is coupled to RNA polymerase II
transcription. Co‐transcriptional RNA processing helps to ensure efficient and proper …
transcription. Co‐transcriptional RNA processing helps to ensure efficient and proper …
Cytoplasmic poly (A) binding protein-1 binds to genomically encoded sequences within mammalian mRNAs
The functions of the major mammalian cytoplasmic poly (A) binding protein, PABPC1, have
been characterized predominantly in the context of its binding to the 3′ poly (A) tails of …
been characterized predominantly in the context of its binding to the 3′ poly (A) tails of …
Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA
P Keil, A Wulf, N Kachariya, S Reuscher… - Nucleic acids …, 2023 - academic.oup.com
RNA-binding proteins (RBPs) control every RNA metabolic process by multiple protein–RNA
and protein–protein interactions. Their roles have largely been analyzed by crude mutations …
and protein–protein interactions. Their roles have largely been analyzed by crude mutations …