BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …

Bidirectional somatic cell–oocyte signaling is essential to create a changing intrafollicular
microenvironment that controls primordial follicle growth into a cohort of growing follicles …

The developing fetus requires substantial amounts of fatty acids to support rapid cellular
growth and activity. Although the fatty acid composition delivered to the fetus is largely …

BACKGROUND While oocyte IVM is practiced sporadically it has not achieved widespread
clinical practice globally. However, recently there have been some seminal advances in our …

In vitro maturation (IVM) offers significant benefits for human infertility treatment and animal
breeding, but this potential is yet to be fully realised due to reduced oocyte developmental …

STUDY QUESTION Can bovine oocyte antioxidant defence and oocyte quality be improved
by extending the duration of pre-in vitro maturation (IVM) with cyclic adenosine mono …

Maternal obese environment has been reported to induce oxidative stress and meiotic
defects in oocytes, however the underlying molecular mechanism remains unclear. Here …

Polycystic ovary syndrome (PCOS) is a common cause of female infertility.
Hyperandrogenism is both a major symptom and key diagnostic trait of PCOS; however, the …

STUDY QUESTION Can a pre-in vitro maturation (pre-IVM) medium containing signaling
molecules rather than chemical/pharmaceutical agents, sustain meiotic arrest and improve …

Oocytes are maintained in a state of meiotic arrest following the first meiotic division until
ovulation is triggered. Within the antral follicle, meiotic arrest is actively suppressed in a …