High rates of virological failure and drug resistance in perinatally HIV‐1‐infected children and adolescents receiving lifelong antiretroviral therapy in routine clinics in …
Introduction Antiretroviral treatment (ART) has been scaled up over the last decade but
compared to adults, children living with HIV are less likely to receive ART. Moreover …
compared to adults, children living with HIV are less likely to receive ART. Moreover …
[HTML][HTML] HIV drug resistance mutations in proviral DNA from a community treatment program
A Derache, HS Shin, M Balamane, E White… - PLoS …, 2015 - journals.plos.org
Background Drug resistance mutations archived in resting memory CD4+ cells may persist
despite suppression of HIV RNA to< 50 copies/ml. We sequenced pol gene from proviral …
despite suppression of HIV RNA to< 50 copies/ml. We sequenced pol gene from proviral …
Antiretroviral resistance patterns in children with HIV infection
J Nuttall, V Pillay - Current Infectious Disease Reports, 2019 - Springer
Abstract Purpose of Review To provide an update on the patterns of HIV drug resistance in
children, including pretreatment drug resistance (PDR) and acquired drug resistance (ADR) …
children, including pretreatment drug resistance (PDR) and acquired drug resistance (ADR) …
[HTML][HTML] Factors associated with the development of drug resistance mutations in HIV-1 infected children failing protease inhibitor-based antiretroviral therapy in South …
Objective Limited data are available from the developing world on antiretroviral drug
resistance in HIV-1 infected children failing protease inhibitor-based antiretroviral therapy …
resistance in HIV-1 infected children failing protease inhibitor-based antiretroviral therapy …
Prevalence of pretreatment and acquired HIV-1 mutations associated with resistance to lamivudine or rilpivirine: a systematic review
V Vannappagari, L Ragone, C Henegar… - Antiviral …, 2019 - journals.sagepub.com
Background Pretreatment and acquired drug resistance mutations (DRMs) can limit
antiretroviral therapy effectiveness. Methods We review prevalence of DRMs with resistance …
antiretroviral therapy effectiveness. Methods We review prevalence of DRMs with resistance …
[HTML][HTML] Genome-wide association study of HIV whole genome sequences validated using drug resistance
RA Power, S Davaniah, A Derache, E Wilkinson… - PLoS …, 2016 - journals.plos.org
Background Genome-wide association studies (GWAS) have considerably advanced our
understanding of human traits and diseases. With the increasing availability of whole …
understanding of human traits and diseases. With the increasing availability of whole …
[HTML][HTML] High levels of virological failure with major genotypic resistance mutations in HIV-1-infected children after 5 years of care according to WHO-recommended 1st …
CD Mossoro-Kpinde, JC Gody, RSM Bouassa… - Medicine, 2017 - journals.lww.com
A large cohort of 220 HIV-1-infected children (median [range] age: 12 [4–17] years) was
cared and followed up in the Central African Republic, including 198 in 1st-line and 22 in …
cared and followed up in the Central African Republic, including 198 in 1st-line and 22 in …
Full-spectrum HIV drug resistance mutation detection by high-resolution complete pol gene sequencing
G Faraci, SY Park, MP Dubé, HY Lee - Journal of Clinical Virology, 2023 - Elsevier
Background Drug resistance mutation testing is a key element for HIV clinical management,
informing effective treatment regimens. However, resistance screening in current clinical …
informing effective treatment regimens. However, resistance screening in current clinical …
High prevalence of virological failure and HIV drug mutations in a first-line cohort of Malawian children
MHW Huibers, P Moons, M Cornelissen… - Journal of …, 2018 - academic.oup.com
Abstract Background Drug resistance mutations (DRMs) increasingly jeopardize paediatric
HIV programmes in sub-Saharan Africa. As individual monitoring of DRMs and viral loads …
HIV programmes in sub-Saharan Africa. As individual monitoring of DRMs and viral loads …
[HTML][HTML] Long-term virological outcome in children receiving first-line antiretroviral therapy
P Chandrasekaran, A Shet, R Srinivasan… - AIDS research and …, 2018 - Springer
Background Studies relating to long-term virological outcomes among children on first-line
antiretroviral therapy (ART) from low and middle-income countries are limited. Methods …
antiretroviral therapy (ART) from low and middle-income countries are limited. Methods …