Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …

Inflammasomes are multi-protein signaling complexes that trigger the activation of
inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome …

Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and
pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of
the cell that are responsible for the maturation of proinflammatory cytokines such as …

IL-1β production is critically regulated by cytosolic molecular complexes, termed
inflammasomes. Different inflammasome complexes have been described to date. While all …

Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …

In reply to internal or external danger stimuli, the body orchestrates an inflammatory
response. The endogenous triggers of this process are the damage-associated molecular …

The production of various reactive oxidant species in excess of endogenous antioxidant
defense mechanisms promotes the development of a state of oxidative stress, with …

Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …