The role of gut microbial β-glucuronidase in drug disposition and development
Gut microbial β-glucuronidase (gmGUS) is involved in the disposition of many endogenous
and exogenous compounds. Preclinical studies have shown that inhibiting gmGUS activity …
and exogenous compounds. Preclinical studies have shown that inhibiting gmGUS activity …
[HTML][HTML] Pharmacokinetic, Metabolism, and Metabolomic Strategies Provide Deep Insight Into the Underlying Mechanism of Ginkgo biloba Flavonoids in the …
Y Tao, F Zhu, M Pan, Q Liu, P Wang - Frontiers in Nutrition, 2022 - frontiersin.org
Ginkgo biloba, known as the “living fossil,” has a long history of being used as botanical
drug for treating cardiovascular diseases and the content of flavonoids as high as 24 …
drug for treating cardiovascular diseases and the content of flavonoids as high as 24 …
Discovery and characterization of the flavonoids in Cortex Mori Radicis as naturally occurring inhibitors against intestinal nitroreductases
X Chen, Y Han, L Chen, QL Tian, YL Yin, Q Zhou… - Chemico-Biological …, 2022 - Elsevier
Gut bacterial nitroreductases are found to be heavily related with the intestinal toxicity of
nitroaromatic compounds in food or medicine, which can be converted into mutagenic and …
nitroaromatic compounds in food or medicine, which can be converted into mutagenic and …
Discovery of a botanical compound as a broad-spectrum inhibitor against gut microbial β-glucuronidases from the Tibetan medicine Rhodiola crenulata
L Chen, XD Hou, GH Zhu, J Huang, ZB Guo… - International Journal of …, 2024 - Elsevier
Gut microbial β-glucuronidases (gmβ-GUS) played crucial roles in regulating a variety of
endogenous substances and xenobiotics on the circulating level, thus had been recognized …
endogenous substances and xenobiotics on the circulating level, thus had been recognized …
Microbiomedriven anticancer therapy: A step forward from natural products
Y Guan, D Wu, H Wang, NN Liu - Mlife, 2024 - Wiley Online Library
Human microbiomes, considered as a new emerging and enabling cancer hallmark, are
increasingly recognized as critical effectors in cancer development and progression …
increasingly recognized as critical effectors in cancer development and progression …
Discovery and characterization of amentoflavone as a naturally occurring inhibitor against the bile salt hydrolase produced by Lactobacillus salivarius
CY Li, HN Wang, RJ He, J Huang, LL Song… - Food & Function, 2022 - pubs.rsc.org
Bile salt hydrolases (BSHs), a group of cysteine-hydrolases produced by gut microbes, play
a crucial role in the hydrolysis of glycine-or taurine-conjugated bile acids and have been …
a crucial role in the hydrolysis of glycine-or taurine-conjugated bile acids and have been …