[HTML][HTML] The scavenger function of liver sinusoidal endothelial cells in health and disease
The aim of this review is to give an outline of the blood clearance function of the liver
sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions …
sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions …
Liver sinusoidal endothelial cells
KK Sørensen, J Simon‐Santamaria… - Comprehensive …, 2011 - Wiley Online Library
The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic
sinusoid and functions as a control post regulating and surveying the trafficking of molecules …
sinusoid and functions as a control post regulating and surveying the trafficking of molecules …
Fc receptors and their role in immune regulation and autoimmunity
T Takai - Journal of clinical immunology, 2005 - Springer
The activation threshold of cells in the immune system is often tuned by cell surface
molecules. The Fc receptors expressed on various hematopoietic cells constitute critical …
molecules. The Fc receptors expressed on various hematopoietic cells constitute critical …
Fc receptors and their interaction with complement in autoimmunity
RE Schmidt, JE Gessner - Immunology letters, 2005 - Elsevier
Genetic studies in mice indicate a crucial role for Fc receptors (FcR) in antibody-mediated
autoimmune diseases. Like other immune regulatory receptor pairs, the FcR system is …
autoimmune diseases. Like other immune regulatory receptor pairs, the FcR system is …
[HTML][HTML] The complex association of FcγRIIb with autoimmune susceptibility
JS Verbeek, S Hirose, H Nishimura - Frontiers in Immunology, 2019 - frontiersin.org
FcγRIIb is the only inhibitory Fc receptor and controls many aspects of immune and
inflammatory responses. The observation 19 years ago that FcγRIIb−/− mice generated by …
inflammatory responses. The observation 19 years ago that FcγRIIb−/− mice generated by …
Targeting the Fc receptor in autoimmune disease
X Li, RP Kimberly - Expert opinion on therapeutic targets, 2014 - Taylor & Francis
Introduction: The Fc receptors (FcRs) and their interactions with immunoglobulin and innate
immune opsonins, such as C-reactive protein, are key players in humoral and cellular …
immune opsonins, such as C-reactive protein, are key players in humoral and cellular …
The regulation of lymphocyte activation by inhibitory receptors
PJ Leibson - Current opinion in immunology, 2004 - Elsevier
The ability of activating immune recognition receptors on lymphocytes to regulate cellular
activation and function can be profoundly altered by co-stimulation with inhibitory receptors …
activation and function can be profoundly altered by co-stimulation with inhibitory receptors …
Augmented TLR9-induced Btk activation in PIR-B–deficient B-1 cells provokes excessive autoantibody production and autoimmunity
T Kubo, Y Uchida, Y Watanabe, M Abe… - Journal of Experimental …, 2009 - rupress.org
Pathogens are sensed by Toll-like receptors (TLRs) expressed in leukocytes in the innate
immune system. However, excess stimulation of TLR pathways is supposed to be connected …
immune system. However, excess stimulation of TLR pathways is supposed to be connected …
[HTML][HTML] Nuclear Factor Erythroid 2-related Factor 2 Deficiency Exacerbates Lupus Nephritis in B6/lpr mice by Regulating Th17 Cell Function
M Zhao, H Chen, Q Ding, X Xu, B Yu, Z Huang - Scientific reports, 2016 - nature.com
Lupus nephritis (LN) is the major clinical manifestation of systemic lupus erythematosus. LN
is promoted by T helper 17 (Th17) cells, which are the major pro-inflammatory T cell subset …
is promoted by T helper 17 (Th17) cells, which are the major pro-inflammatory T cell subset …
[HTML][HTML] Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIb, yet maintain a preserved fenestration in the …
MB Antwi, G Dumitriu, J Simón-Santamaria… - Plos one, 2023 - journals.plos.org
Liver sinusoidal endothelial cells (LSECs) are fenestrated endothelial cells with a unique,
high endocytic clearance capacity for blood-borne waste macromolecules and colloids. This …
high endocytic clearance capacity for blood-borne waste macromolecules and colloids. This …