Progress and potential in organoid research
G Rossi, A Manfrin, MP Lutolf - Nature Reviews Genetics, 2018 - nature.com
Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …
hindered, particularly in humans, by sample accessibility and ethical concerns. However …
Three-dimensional cell cultures in drug discovery and development
Y Fang, RM Eglen - Slas discovery: Advancing Life Sciences …, 2017 - journals.sagepub.com
The past decades have witnessed significant efforts toward the development of three-
dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D …
dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D …
Novel insights into the function of CD24: A driving force in cancer
CD24 is a highly glycosylated protein with a small protein core that is linked to the plasma
membrane via a glycosyl‐phosphatidylinositol anchor. CD24 is primarily expressed by …
membrane via a glycosyl‐phosphatidylinositol anchor. CD24 is primarily expressed by …
Organoid technology and applications in cancer research
H Xu, X Lyu, M Yi, W Zhao, Y Song, K Wu - Journal of hematology & …, 2018 - Springer
During the past decade, the three-dimensional organoid technology has sprung up and
become more and more popular among researchers. Organoids are the miniatures of in vivo …
become more and more popular among researchers. Organoids are the miniatures of in vivo …
Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells
U Testa, E Pelosi, G Castelli - Medical Sciences, 2018 - mdpi.com
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
Hydrogel microenvironments for cancer spheroid growth and drug screening
Y Li, E Kumacheva - Science advances, 2018 - science.org
Multicellular cancer spheroids (MCSs) have emerged as a promising in vitro model that
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …
Nanomaterials for theranostics: recent advances and future challenges
In 2004, the US Food and Drug Administration (FDA) released an important report entitled
“Innovation/Stagnation: Challenge and Opportunity on the Critical Path to New Medical …
“Innovation/Stagnation: Challenge and Opportunity on the Critical Path to New Medical …
Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas
Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
Organogenesis in a dish: modeling development and disease using organoid technologies
MA Lancaster, JA Knoblich - Science, 2014 - science.org
Background Because of their differentiation potential, pluripotent stem cells can generate
virtually any cell type and, as such, can be used to model development and disease and …
virtually any cell type and, as such, can be used to model development and disease and …
Cancer stem cells in colorectal cancer: a review
MJ Munro, SK Wickremesekera, L Peng… - Journal of clinical …, 2018 - jcp.bmj.com
Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men. Adenocarcinoma accounts for 90% of CRC cases. There has been …
common in men. Adenocarcinoma accounts for 90% of CRC cases. There has been …