The glutathione transferases, a family of multifunctional proteins, catalyze the glutathione
conjugation reaction with electrophilic compounds biotransformed from xenobiotics …

The current knowledge about the structure of GST genes and the molecular mechanisms
involved in regulation of their expression are reviewed. Information derived from the study of …

We describe here a novel member of the bZIP family of DNA-binding proteins, designated
E4BP4, that displays an unusual DNA-binding specificity which overlaps that of the …

The rat GST-P (placental glutathione S-transferase), a phase II detoxifying enzyme, is not
expressed in normal liver cells, but is highly and specifically induced during early …

Glutathione and glutathione-dependent enzymes are ubiquitously distributed through
nature. These enzyme systems appear to have evolved to protect cells from toxic and …

Pi class GSTs (glutathione S-transferases) are a member of the vertebrate GST family of
proteins that catalyse the conjugation of GSH to electrophilic compounds. The expression of …

High levels of expression of GSTP1-1 are associated with cell proliferation, embryogenesis
and malignancy. Given the role of glutathione S-transferase (GST) in detoxication, it is …

Background & Aims: In colorectal adenoma and carcinoma, glutathione S-transferase-π
(GSTP1-1) is highly expressed. K-ras mutation is also known to occur frequently in colorectal …

Abstract The bZIP factor E4BP4 overlaps in DNA binding site specificity with the
transcriptional activator CREB and members of the ATF family of transcription factors, but is …

Publisher Summary The glutathione S-transferases (GSTs) catalyze a range of reactions of
glutathione (GSH) with hydrophobic electrophiles. Their most established role is the …