Elderly individuals are the most susceptible to an aggressive form of coronavirus disease
(COVID-19), caused by SARS-CoV-2. The remodeling of immune response that is observed …

The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …

The aging process worsens the human body functions at multiple levels, thus causing its
gradual decrease to resist stress, damage, and disease. Besides changes in gene …

The role of the microbiome in human aging is important: the microbiome directly impacts
aging through the gastrointestinal system. However, the microbial impact on skin has yet to …

As global life expectancy continues to rise, we are challenged with maintaining health into
old age. One strategy is to target the chronic low-level inflammation associated with aging …

The signaling networks that drive the aging process, associated functional deterioration, and
pathologies has captured the scientific community's attention for decades. While many …

The microtubule-associated protein tau aggregates in multiple neurodegenerative diseases,
causing inflammation and changing the inflammatory signature of microglia by unknown …

Skin aging is associated with the accumulation of senescent cells and is related to many
pathological changes, including decreased protection against pathogens, increased …

Cellular senescence was first described as a failure of normal human cells to divide
indefinitely in culture. Until recently, the emphasis in the study of cell senescence has been …

Intrinsic capacity is the sum of an individual's physical and mental capacities, which helps
determine functional ability. Intrinsic capacity decline is an important predictor of adverse …