The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains
unclear. A total of 430 participants were recruited for the screening of differentially …

Abstract Circular RNAs (CircRNAs) are a novel subset of non-coding RNA widely present in
eukaryotes that play a central role in physiological and pathological conditions …

Background Oxytocin (OT) is a neuropeptide hormone that has many beneficial biological
effects, including protection against age‐related disorders. However, less is known about its …

Psoriasis is a chronic Th1/Th17 lymphocytes-mediated inflammatory skin disease, in which
epidermal keratinocytes exhibit a peculiar senescent state, resistance to apoptosis and the …

Hormone-regulated proliferation and differentiation of endometrial stromal cells (ESCs)
determine overall endometrial plasticity and receptivity to embryos. Previously we revealed …

The aging process intricately involves immune system dynamics, with a crucial role in
managing senescent cells (SNCs) and their senescence-associated secretory phenotypes …

Aging is a normal, progressive and multi-step degeneration in the physiological functions
and metabolic processes of living organisms until death. It represents the main risk factor for …

Aging probably is the most complexed process in biology. It is manifested by a variety of
hallmarks. These hallmarks weave a network of aging; however, each hallmark is not …

Arginases are key enzymes that hydrolyze L-arginine to urea and L-ornithine in the urea
cycle. The two arginase isoforms, arginase 1 (ARG1) and arginase 2 (ARG2), regulate the …

Transdifferentiation (or activation) of hepatic stellate cells (HSCs) to myofibroblasts is a key
event in liver fibrosis. Activated HSCs in the tumor microenvironment reportedly promote …