The effect of HIF on metabolism and immunity

CT Taylor, CC Scholz - Nature Reviews Nephrology, 2022 - nature.com
Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to
produce the levels of ATP required to perform physiological functions exceeds the vascular …

Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Oxidative stress and inflammation biomarker expression in obstructive sleep apnea patients

A Maniaci, G Iannella, S Cocuzza, C Vicini… - Journal of Clinical …, 2021 - mdpi.com
Obstructive Sleep Apnea Syndrome (OSAS) is a respiratory sleep disorder characterised by
repeated episodes of partial or complete obstruction of the upper airway during the night …

Persistent Oxidative Stress and Inflammasome Activation in CD14highCD16 Monocytes From COVID-19 Patients

SL Lage, EP Amaral, KL Hilligan, E Laidlaw… - Frontiers in …, 2022 - frontiersin.org
The poor outcome of the coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is
associated with systemic hyperinflammatory response and immunopathology. Although …

The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF‐1α to inhibit knee osteoarthritis‐induced ferroptosis

Z Guan, X Jin, Z Guan, S Liu, K Tao, L Luo - Aging Cell, 2023 - Wiley Online Library
Ferroptosis is an iron‐dependent cell death that has been found to aggravate the
progression of osteoarthritis (OA) and gut microbiota‐OA axis refers to the bidirectional …

NLRP3 deficiency protects against intermittent hypoxia-induced neuroinflammation and mitochondrial ROS by promoting the PINK1-parkin pathway of mitophagy in a …

X Wu, L Gong, L Xie, W Gu, X Wang, Z Liu… - Frontiers in …, 2021 - frontiersin.org
Obstructive sleep apnea (OSA) associated neurocognitive impairment is mainly caused by
chronic intermittent hypoxia (CIH)-triggered neuroinflammation and oxidative stress …

Selenium status and its antioxidant role in metabolic diseases

J Huang, L Xie, A Song, C Zhang - Oxidative Medicine and …, 2022 - Wiley Online Library
Selenium (Se), in the form of selenoproteins, is an essential micronutrient that plays an
important role in human health and disease. To date, there are at least 25 selenoproteins in …

Gene regulation by histone-modifying enzymes under hypoxic conditions: a focus on histone methylation and acetylation

J Kim, H Lee, SJ Yi, K Kim - Experimental & Molecular Medicine, 2022 - nature.com
Oxygen, which is necessary for sustaining energy metabolism, is consumed in many
biochemical reactions in eukaryotes. When the oxygen supply is insufficient for maintaining …

NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors

Y Xu, Y Yang, X Chen, D Jiang, F Zhang, Y Guo… - Translational …, 2023 - Springer
Cognitive impairment is a multifactorial and multi-step pathological process that places a
heavy burden on patients and the society. Neuroinflammation is one of the main factors …