A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection
DA Jamison Jr, S Anand Narayanan… - European Journal of …, 2022 - nature.com
COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives
and 257 million cases reported globally. This virus and disease have significantly affected …
and 257 million cases reported globally. This virus and disease have significantly affected …
DAMPs, MAMPs, and NAMPs in plant innate immunity
HW Choi, DF Klessig - BMC plant biology, 2016 - Springer
Background Multicellular organisms have evolved systems/mechanisms to detect various
forms of danger, including attack by microbial pathogens and a variety of pests, as well as …
forms of danger, including attack by microbial pathogens and a variety of pests, as well as …
Beclin-1-dependent autophagy protects the heart during sepsis
Background: Cardiac dysfunction is a major component of sepsis-induced multiorgan failure
in critical care units. Changes in cardiac autophagy and its role during sepsis pathogenesis …
in critical care units. Changes in cardiac autophagy and its role during sepsis pathogenesis …
Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy
H Kong, H Zhao, T Chen, Y Song, Y Cui - Cell Death & Disease, 2022 - nature.com
Retinal endothelial cells (RECs) are the primary target cells for diabetes-induced vascular
damage. The P2X7/NLRP3 pathway plays an essential role in amplifying inflammation via …
damage. The P2X7/NLRP3 pathway plays an essential role in amplifying inflammation via …
Connexins in cardiovascular and neurovascular health and disease: pharmacological implications
Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
Physiology and pathophysiology of purinergic neurotransmission
G Burnstock - Physiological reviews, 2007 - journals.physiology.org
This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …
[HTML][HTML] Nucleotide-and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade
GG Yegutkin - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2008 - Elsevier
The involvement of extracellular nucleotides and adenosine in an array of cell-specific
responses has long been known and appreciated, but the integrative view of purinergic …
responses has long been known and appreciated, but the integrative view of purinergic …
Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities
GG Yegutkin - Critical reviews in biochemistry and molecular …, 2014 - Taylor & Francis
Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …
organs and tissues. Most models of purinergic signaling depend on functional interactions …
Crystal structure of the ATP-gated P2X4 ion channel in the closed state
P2X receptors are cation-selective ion channels gated by extracellular ATP, and are
implicated in diverse physiological processes, from synaptic transmission to inflammation to …
implicated in diverse physiological processes, from synaptic transmission to inflammation to …
C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation
E Asgari, G Le Friec, H Yamamoto… - Blood, The Journal …, 2013 - ashpublications.org
Abstract Interleukin-1β (IL-1β) is a proinflammatory cytokine and a therapeutic target in
several chronic autoimmune states. Monocytes and macrophages are the major sources of …
several chronic autoimmune states. Monocytes and macrophages are the major sources of …