The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …

Protein S‐palmitoylation is a reversible post‐translational modification that alters the
localization, stability, and function of hundreds of proteins in the cell. S‐palmitoylation is …

Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains
unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in …

Wnt signalling is essential for regulation of embryonic development and adult tissue
homeostasis,–, and aberrant Wnt signalling is frequently associated with cancers. Wnt …

Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …

Abstract Angiotensin converting enzyme 2 (ACE2) is a key receptor present on cell surfaces
that directly interacts with the viral spike (S) protein of the severe acute respiratory syndrome …

Protein lipidation is an important co-or posttranslational modification in which lipid moieties
are covalently attached to proteins. Lipidation markedly increases the hydrophobicity of …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Summary p62 is a well-characterized autophagy receptor that recognizes and sequesters
specific cargoes into autophagosomes for degradation. p62 promotes the assembly and …

The nucleotide oligomerization domain (NOD)–like receptors 1 and 2 (NOD1/2) are
intracellular pattern-recognition proteins that activate immune signaling pathways in …