Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease
Amyloid-β and tau are the two hallmark proteins in Alzheimer's disease. Although both
amyloid-β and tau have been extensively studied individually with regard to their separate …
amyloid-β and tau have been extensively studied individually with regard to their separate …
Genetics of Alzheimer disease
LM Bekris, CE Yu, TD Bird… - Journal of geriatric …, 2010 - journals.sagepub.com
Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the
elderly individuals. Clinically, patients initially present with short-term memory loss …
elderly individuals. Clinically, patients initially present with short-term memory loss …
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration
The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …
essential for cellular homeostasis, development, and stress responsiveness. In response to …
Phosphatidylethanolamine metabolism in health and disease
E Calzada, O Onguka, SM Claypool - … review of cell and molecular biology, 2016 - Elsevier
Phosphatidylethanolamine (PE) is the second most abundant glycerophospholipid in
eukaryotic cells. The existence of four only partially redundant biochemical pathways that …
eukaryotic cells. The existence of four only partially redundant biochemical pathways that …
Role of metals in Alzheimer's disease
N Das, J Raymick, S Sarkar - Metabolic brain disease, 2021 - Springer
Metal homeostasis in the central nervous system (CNS) is a crucial component of healthy
brain function, because metals serve as enzymatic cofactors and are key components of …
brain function, because metals serve as enzymatic cofactors and are key components of …
Endoplasmic reticulum–mitochondria signaling in neurons and neurodegenerative diseases
A Markovinovic, J Greig… - Journal of Cell …, 2022 - journals.biologists.com
Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …
[HTML][HTML] The P2X7 receptor: central hub of brain diseases
R Andrejew, Á Oliveira-Giacomelli… - Frontiers in Molecular …, 2020 - frontiersin.org
The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …
Bioinorganic chemistry of Alzheimer's disease
KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease
E Area‐Gomez, M del Carmen Lara Castillo… - The EMBO …, 2012 - embopress.org
Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor
protein (APP) by γ‐secretase, via an unknown mechanism. We recently showed that …
protein (APP) by γ‐secretase, via an unknown mechanism. We recently showed that …
A review of theta oscillation and its functional correlates
S Karakaş - International Journal of Psychophysiology, 2020 - Elsevier
Theta is an extensively studied oscillation of the nervous system, but there is only a paucity
of reviews on the subject. A review of specifically the cognitive-affective correlates of the …
of reviews on the subject. A review of specifically the cognitive-affective correlates of the …