[HTML][HTML] Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics

D Li, Y Li, S Yang, J Lu, X Jin, M Wu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The prevalence of metabolic diseases, including obesity, dyslipidemia, type 2 diabetes
mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), is a severe burden in human …

[HTML][HTML] TLR2 and TLR4 in Parkinson's disease pathogenesis: The environment takes a toll on the gut

AM Gorecki, CC Anyaegbu, RS Anderton - Translational …, 2021 - Springer
Parkinson's disease (PD) is an incurable, devastating disorder that is characterized by
pathological protein aggregation and neurodegeneration in the substantia nigra. In recent …

[HTML][HTML] Butyrate protects mice against methionine–choline-deficient diet-induced non-alcoholic steatohepatitis by improving gut barrier function, attenuating …

J Ye, L Lv, W Wu, Y Li, D Shi, D Fang, F Guo… - Frontiers in …, 2018 - frontiersin.org
Butyrate exerts protective effects against non-alcoholic steatohepatitis (NASH), but the
underlying mechanisms are unclear. We aimed to investigate the role of butyrate-induced …

[HTML][HTML] Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development

J Allen, CL Sears - Genome medicine, 2019 - Springer
In recent years, the number of studies investigating the impact of the gut microbiome in
colorectal cancer (CRC) has risen sharply. As a result, we now know that various microbes …

Anti-senescence compounds: a potential nutraceutical approach to healthy aging

F Gurău, S Baldoni, F Prattichizzo, E Espinosa… - Ageing Research …, 2018 - Elsevier
The desire of eternal youth seems to be as old as mankind. However, the increasing life
expectancy experienced by populations in developed countries also involves a significantly …

Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation

L Chen, B Jiang, C Zhong, J Guo, L Zhang… - …, 2018 - academic.oup.com
Freeze-dried black raspberry (BRB) powder is considered as a potential cancer
chemopreventive agent. In this study, we fed azoxymethane (AOM)/dextran sodium sulfate …

[HTML][HTML] Organic acids as alternatives for antibiotic growth promoters alter the intestinal structure and microbiota and improve the growth performance in broilers

D Dai, K Qiu, H Zhang, S Wu, Y Han, Y Wu… - Frontiers in …, 2021 - frontiersin.org
The present study aimed to investigate the effects of organic acids (OA) as alternatives for
antibiotic growth promoters (AGP) on growth performance, intestinal structure, as well as …

[HTML][HTML] 27-Hydroxycholesterol contributes to cognitive deficits in APP/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction

Y Wang, Y An, W Ma, H Yu, Y Lu, X Zhang… - Journal of …, 2020 - Springer
Background Research on the brain-gut-microbiota axis has led to accumulating interest in
gut microbiota dysbiosis and intestinal barrier dysfunction in Alzheimer's disease (AD). Our …

Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications

J Wu, Y Zhao, X Wang, L Kong… - Critical reviews in …, 2022 - Taylor & Francis
The imbalance of intestinal microecology firstly impairs intestinal mucosa barrier and
function, then further damages the functions and homeostasis of distal organs, leading to …

[HTML][HTML] Secretome of Intestinal Bacilli: A Natural Guard against Pathologies

ON Ilinskaya, VV Ulyanova, DR Yarullina… - Frontiers in …, 2017 - frontiersin.org
Current studies of human gut microbiome usually do not consider the special functional role
of transient microbiota, although some of its members remain in the host for a long time and …