Background Hypertension is a life-threatening disease mainly featured as vascular
endothelial dysfunction. This study aims to explore the regulatory role of murine double …

Recently, H2O2 has been identified as the endothelium-dependent hyperpolarizing factor
(EDHF), which mediates flow-induced dilation in human coronary arteries. Neuronal nitric …

Obesity is characterized by abnormal adipose tissue expansion and is associated with
chronic inflammation. Obesity itself may induce several comorbidities, including psychiatric …

Cardiovascular diseases encompass a range of pathologies that affect the heart or blood
vessels. Oxidative stress is an important factor that contributes to the development of these …

Bronchial obstruction, a frequently encountered medical condition, is caused by a
mechanical or immunological response or pathological blockage of any part of the airways …

B1-and B2-kinin receptors are G protein-coupled receptors that play an important role in the
vascular function. Therefore, the present study was designed to evaluate the participation of …

Background: NOX4 activation has been implicated to have vasoprotective and blood
pressure (BP)-lowering effects. Molecular mechanisms underlying this are unclear, but …

Lymphedema is a disease that occurs when lymph flow is impaired, resulting in tissue
swelling, fibrosis, chronic inflammation and recurrent secondary infections. Lymphatic valves …

Introduction: The diseased host milieu, such as endothelial dysfunction (ED), decreased NO
bioavailability, and ischemic/inflammatory post-MI environment, hamper the clinical success …

In arteries, endothelium‐dependent vasodilatory agonists and flow‐induced shear stress
cause vasodilation largely by activation of the endothelial enzyme eNOS, which generates …