A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities

P Artigas, DJ Meyer, VC Young… - Proceedings of the …, 2023 - National Acad Sciences
Brine shrimp (Artemia) are the only animals to thrive at sodium concentrations above 4 M.
Salt excretion is powered by the Na+, K+-ATPase (NKA), a heterodimeric (αβ) pump that …

From ecology to oncology: To understand cancer stem cell dormancy, ask a Brine shrimp (Artemia)

CR Wood, WT Wu, YS Yang, JS Yang, Y Xi… - Advances in Cancer …, 2023 - Elsevier
The brine shrimp (Artemia), releases embryos that can remain dormant for up to a decade.
Molecular and cellular level controlling factors of dormancy in Artemia are now being …

Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension

H Le Ribeuz, L To, MR Ghigna, C Martin… - European …, 2021 - Eur Respiratory Soc
Introduction A reduction in pulmonary artery relaxation is a key event in the pathogenesis of
pulmonary arterial hypertension (PAH). Cystic fibrosis transmembrane conductance …

Function of ion transporters in maintaining acid-base homeostasis of the mammary gland and the pathophysiological role in breast cancer

Z Ma, D Yuan, X Cheng, B Tuo… - American Journal of …, 2020 - journals.physiology.org
The incidence of breast cancer is increasing year by year, and the pathogenesis is still
unclear. Studies have shown that the high metabolism of solid tumors leads to an increase …

Setd4 confers cancer stem cell chemoresistance in nonsmall cell lung cancer patients via the epigenetic regulation of cellular quiescence

Y Wang, Y Yu, W Yang, L Wu, Y Yang… - Stem Cells …, 2023 - Wiley Online Library
Increasing evidence indicates that quiescent cancer stem cells (CSCs) are a root cause of
chemoresistance. SET domain‐containing protein 4 (SETD4) epigenetically regulates cell …

A transcriptomic examination of encased rotifer embryos reveals the developmental trajectory leading to long-term dormancy; are they “animal seeds”?

T Hashimshony, L Levin, AC Fröbius, N Dahan… - BMC genomics, 2024 - Springer
Background Organisms from many distinct evolutionary lineages acquired the capacity to
enter a dormant state in response to environmental conditions incompatible with maintaining …

Spatio-temporal patterns of ovarian development and VgR gene silencing reduced fecundity in parthenogenetic Artemia

H Duan, X Shao, W Liu, J Xiang, N Pan… - Open …, 2023 - royalsocietypublishing.org
The halophilic zooplankton brine shrimp Artemia has been used as an experimental animal
in multidisciplinary studies. However, the reproductive patterns and its regulatory …

Hypersaline lagoons from Chile, the southern edge of the world

G Gajardo, S Redón - Lagoon Environments Around the World-A …, 2019 - books.google.com
Hypersaline lagoons distributed in arid and semiarid regions are unique ecosystems with
unique value stemming from their extremophile biodiversity, limnological properties and …

Downregulation of a CT10 regulator of kinase (Crk) promotes the formation of diapause embryos in the brine shrimp Artemia

ZJ Yan, WT Wu, LY Xu, N Bi, F Yang, WJ Yang… - Gene, 2023 - Elsevier
To survive under harsh environments, embryonic development of Artemia was arrested at
the gastrula stage and released as the diapause embryo. Cell cycle and metabolism were …

Ferroptosis is determined by chloride ions

D Huang, Z Dai, C Wang, H Mai, J Zhao, L Cao… - bioRxiv, 2023 - biorxiv.org
Ferroptosis has emerged as a deliberate type of programmed cell death that manifests
marked importance ubiquitously in health and diseases. However, after a decade of …