Chemical basis of combination therapy to combat antibiotic resistance

Z Si, K Pethe, MB Chan-Park - JACS Au, 2023 - ACS Publications
The antimicrobial resistance crisis is a global health issue requiring discovery and
development of novel therapeutics. However, conventional screening of natural products or …

Antimicrobial natural hydrogels in biomedicine: Properties, Applications, and challenges—A concise review

O Kapusta, A Jarosz, K Stadnik… - International Journal of …, 2023 - mdpi.com
Natural hydrogels are widely used as biomedical materials in many areas, including drug
delivery, tissue scaffolds, and particularly wound dressings, where they can act as an …

Development of novel peptide-modified silver nanoparticle-based rapid biosensors for detecting aminoglycoside antibiotics

DY Kim, SK Sharma, K Rasool, JR Koduru… - Journal of Agricultural …, 2023 - ACS Publications
The detection and monitoring of aminoglycoside antibiotics (AGAs) have become of utmost
importance due to their widespread use in human and animal therapy, as well as the …

Antibiotic action and resistance: updated review of mechanisms, spread, influencing factors, and alternative approaches for combating resistance

EM Halawa, M Fadel, MW Al-Rabia… - Frontiers in …, 2024 - frontiersin.org
Antibiotics represent a frequently employed therapeutic modality for the management of
bacterial infections across diverse domains, including human health, agriculture, livestock …

Encapsulating Antibiotic and Protein-Stabilized Nanosilver into Sandwich-Structured Electrospun Nanofibrous Scaffolds for MRSA-Infected Wound Treatment

L Cai, L Zhang, J Yang, X Zhu, W Wei, M Ji… - … Applied Materials & …, 2023 - ACS Publications
With the increasing prevalence of microbial infections, which results in prolonged
inflammation and delayed wound healing, the development of effective and safe …

Membrane-active cyclic amphiphilic peptides: Broad-spectrum antibacterial activity alone and in combination with antibiotics

EHM Mohammed, S Lohan, T Ghaffari… - Journal of Medicinal …, 2022 - ACS Publications
We designed a library of 24 cyclic peptides containing arginine (R) and tryptophan (W)
residues in a sequential manner [R n W n](n= 2–7) to study the impact of the hydrophilic …

Uracil restores susceptibility of methicillin-resistant Staphylococcus aureus to aminoglycosides through metabolic reprogramming

L Fan, Z Pan, X Liao, Y Zhong, J Guo, R Pang… - Frontiers in …, 2023 - frontiersin.org
Background: Methicillin-resistant Staphylococcus aureus (MRSA) has now become a major
nosocomial pathogen bacteria and resistant to many antibiotics. Therefore, Development of …

Exploring antibiotic resistance with chemical tools

WA Velema - Chemical Communications, 2023 - pubs.rsc.org
Antibiotic resistance is an enormous problem that is accountable for over a million deaths
annually, with numbers expected to significantly increase over the coming decades …

Anti-Staphylococcal Activities of Rosmarinus officinalis and Myrtus communis Essential Oils through ROS-Mediated Oxidative Stress

KH Bowbe, KBH Salah, S Moumni, MF Ashkan… - Antibiotics, 2023 - mdpi.com
Rosmarinus officinalis and Myrtus communis essential oils (EOs) are well-known for their
ethno-pharmaceutical properties. In the present study, we have analyzed the chemical …

Nanomedicine to overcome antimicrobial resistance: Challenges and prospects

W Zou, A McAdorey, H Yan, W Chen - Nanomedicine, 2023 - Taylor & Francis
Translation of antibacterial nanoparticles into nanomedicine requires a deep understanding
of the dynamic nature of nanoparticles and the ways they overcome immunological and …