Atopic dermatitis: an expanding therapeutic pipeline for a complex disease
T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …
Standard classification and pathophysiology of rosacea: the 2017 update by the National Rosacea Society Expert Committee
In 2002, the National Rosacea Society assembled an expert committee to develop the first
standard classification of rosacea. This original classification was intended to be updated as …
standard classification of rosacea. This original classification was intended to be updated as …
Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice
F De Logu, R Nassini, A Hegron, L Landini… - Nature …, 2022 - nature.com
Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its
receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) …
receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) …
Interleukin‐31: The “itchy” cytokine in inflammation and therapy
The cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …
[PDF][PDF] Cellular taxonomy of the mouse striatum as revealed by single-cell RNA-seq
The striatum contributes to many cognitive processes and disorders, but its cell types are
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …
Role of substance P neuropeptide in inflammation, wound healing, and tissue homeostasis
S Suvas - The Journal of Immunology, 2017 - journals.aai.org
Substance P (SP) is an undecapeptide present in the CNS and the peripheral nervous
system. SP released from the peripheral nerves exerts its biological and immunological …
system. SP released from the peripheral nerves exerts its biological and immunological …
Neuroendocrine control of gonadotropin‐releasing hormone: pulsatile and surge modes of secretion
RL Goodman, AE Herbison… - Journal of …, 2022 - Wiley Online Library
The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …
releasing hormone (GnRH) was well established by the time that GnRH was identified and …
Substance P and pain chronicity
W Zieglgänsberger - Cell and tissue research, 2019 - Springer
Substance P (SP) is a highly conserved member of the tachykinin peptide family that is
widely expressed throughout the animal kingdom. The numerous members of the tachykinin …
widely expressed throughout the animal kingdom. The numerous members of the tachykinin …
Neuropeptides and microglial activation in inflammation, pain, and neurodegenerative diseases
L Carniglia, D Ramírez, D Durand… - Mediators of …, 2017 - Wiley Online Library
Microglial cells are responsible for immune surveillance within the CNS. They respond to
noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory …
noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory …
[PDF][PDF] An intestinal organ culture system uncovers a role for the nervous system in microbe-immune crosstalk
N Yissachar, Y Zhou, L Ung, NY Lai, JF Mohan… - Cell, 2017 - cell.com
Investigation of host-environment interactions in the gut would benefit from a culture system
that maintained tissue architecture yet allowed tight experimental control. We devised a …
that maintained tissue architecture yet allowed tight experimental control. We devised a …