Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

Standard classification and pathophysiology of rosacea: the 2017 update by the National Rosacea Society Expert Committee

RL Gallo, RD Granstein, S Kang, M Mannis… - Journal of the American …, 2018 - Elsevier
In 2002, the National Rosacea Society assembled an expert committee to develop the first
standard classification of rosacea. This original classification was intended to be updated as …

Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice

F De Logu, R Nassini, A Hegron, L Landini… - Nature …, 2022 - nature.com
Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its
receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) …

Interleukin‐31: The “itchy” cytokine in inflammation and therapy

A Datsi, M Steinhoff, F Ahmad, M Alam, J Buddenkotte - Allergy, 2021 - Wiley Online Library
The cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …

[PDF][PDF] Cellular taxonomy of the mouse striatum as revealed by single-cell RNA-seq

O Gokce, GM Stanley, B Treutlein, NF Neff, JG Camp… - Cell reports, 2016 - cell.com
The striatum contributes to many cognitive processes and disorders, but its cell types are
incompletely characterized. We show that microfluidic and FACS-based single-cell RNA …

Role of substance P neuropeptide in inflammation, wound healing, and tissue homeostasis

S Suvas - The Journal of Immunology, 2017 - journals.aai.org
Substance P (SP) is an undecapeptide present in the CNS and the peripheral nervous
system. SP released from the peripheral nerves exerts its biological and immunological …

Neuroendocrine control of gonadotropin‐releasing hormone: pulsatile and surge modes of secretion

RL Goodman, AE Herbison… - Journal of …, 2022 - Wiley Online Library
The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …

Substance P and pain chronicity

W Zieglgänsberger - Cell and tissue research, 2019 - Springer
Substance P (SP) is a highly conserved member of the tachykinin peptide family that is
widely expressed throughout the animal kingdom. The numerous members of the tachykinin …

Neuropeptides and microglial activation in inflammation, pain, and neurodegenerative diseases

L Carniglia, D Ramírez, D Durand… - Mediators of …, 2017 - Wiley Online Library
Microglial cells are responsible for immune surveillance within the CNS. They respond to
noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory …

[PDF][PDF] An intestinal organ culture system uncovers a role for the nervous system in microbe-immune crosstalk

N Yissachar, Y Zhou, L Ung, NY Lai, JF Mohan… - Cell, 2017 - cell.com
Investigation of host-environment interactions in the gut would benefit from a culture system
that maintained tissue architecture yet allowed tight experimental control. We devised a …