Vascular aging, featuring endothelial dysfunction and large elastic artery stiffening, is a
major risk factor for the development of age-associated cardiovascular diseases (CVDs) …

Significance: The vasculature responds to the respiratory needs of tissue by modulating
luminal diameter through smooth muscle constriction or relaxation. Coronary perfusion …

Peripheral artery disease (PAD) is an atherosclerotic disease that impairs blood flow and
muscle function in the lower limbs. A skeletal muscle myopathy characterized by …

Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the leg arteries,
which causes claudication. This may be in part due to vascular mitochondrial dysfunction …

Fibroblast-like synoviocytes (FLS) play an important role in maintaining joint homeostasis
and orchestrating local inflammatory processes. When activated during injury or …

Aging is accompanied by declining lung function and increasing susceptibility to lung
diseases. The role of endothelial dysfunction and vascular remodeling in these changes is …

Highlights•Oxygen demand is central in the control of exercise hyperemia.•Exercise
hyperemia involves a number of vasodilator mechanisms.•Multiple interactions between …

Recognizing the age-related decline in skeletal muscle feed artery (SMFA) vasodilatory
function, this study examined the link between vasodilatory and mitochondrial respiratory …

Introduction. Vascular endothelial dysfunction is characterised by lowered nitric oxide (NO)
bioavailability, which may be explained by increased production of reactive oxygen species …

Hypertension has been described as a condition of premature vascular aging, relative to
actual chronological age. In fact, many factors that contribute to the deterioration of vascular …