Animals have evolved circadian rhythms to adapt to the 24-h day-night cycle. Circadian
rhythms are controlled by molecular clocks in the brain and periphery, which is driven by …

Glucocorticoids are the mainstay of asthma management and effectively treat acute
exacerbations of asthma. However, a small subset of asthmatics, usually with severe …

PI3K activation plays a central role in the development of pulmonary inflammation and tissue
remodeling. PI3K inhibitors may thus offer an improved therapeutic opportunity to treat non …

Uveitis is an immune eye disease that can seriously impair vision. Glucocorticoids (GC S)
have been extensively used to treat uveitis, though the mechanisms have not been fully …

Abstract Treatment failure occurs in up to 30% of patients treated with steroids for
inflammatory diseases. The aim of this study was to explore the potential role of 21 cytokines …

8-Hydroxydaidzein (8-HD) is a daidzein metabolite isolated from soybeans. This compound
has been studied for its anti-proliferation, depigmentation, and antioxidant activities …

BACKGROUND: Previous studies have indicated that oxidative stress plays an important
role in the pathogenesis of chronic obstructive pulmonary disease (COPD). OBJECTIVES …

Substantial evidence indicates that cigarette smoke exposure induces resistance to
glucocorticoids, the primary maintenance medication in asthma treatment. Modest evidence …

Magnolol (1) isolated from Magnolia officinalis exhibits many beneficial effects such as anti-
inflammatory and antioxidant activity. The aim of this study was to evaluate the effects of …

Environmental cues such as the day–night cycle or stressors trigger the production of
glucocorticoids (GCs) by the adrenal cortex. GCs are well known for their anti-inflammatory …